K2644
Kisspeptin-234 trifluoroacetate salt
≥95% (HPLC)
Synonym(s):
kisspeptin-10 peptide 234
About This Item
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
film
color
colorless to white
solubility
H2O: >1 mg/mL
storage temp.
−20°C
1 of 4
This Item | D0444 | SML2626 | D8571 |
---|---|---|---|
100 | 200 | - | 100 |
film | film | film | powder |
−20°C | −20°C | −20°C | −20°C |
colorless to white | colorless to white | white to beige | white to off-white |
H2O: >1 mg/mL | H2O: 0.5 mg/mL, clear | - | H2O: >2 mg/mL |
Biochem/physiol Actions
Gonadotropin-releasing hormone (GnRH) modulates the hypothalamic-pituitary-gonadal axis, enabling the brain to control reproductive processes. Kisspeptin-1 is a peptide neurotransmitter released from afferent neurons onto GnRH neurons, where it binds to and activates to the orphan receptor GPR-54 to regulate release of GnRH. Regulation of kisspeptin/GPR-54 signaling presents an opportunity for reproductive therapeutics above the level of GnRH and gonadotropin secretion. Pharmacological and selective tools are needed to better understand kisspeptin-1/GPR-54 signaling. Analogs of kisspeptin-10, a 10-amino acid portion of kisspeptin-1, were designed to be full and neutral antagonists of GPR-54.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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