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F0285200

Flurbiprofen

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(±)-2-Fluoro-α-methyl-4-biphenylacetic acid, L-790,330

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About This Item

Linear Formula:
C6H5C6H3(F)CH(CH3)CO2H
CAS Number:
5104-49-4
Molecular Weight:
244.26
MDL number:
MFCD00079303
UNSPSC Code:
41116107
PubChem Substance ID:
329799649
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

flurbiprofen

manufacturer/tradename

EDQM

mp

110-112 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2

InChI

1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)

InChI key

SYTBZMRGLBWNTM-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Flurbiprofen EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

F0285202

Flurbiprofen impurity A, European Pharmacopoeia (EP) Reference Standard

1285750

Flurbiprofen, United States Pharmacopeia (USP) Reference Standard

1285760

Flurbiprofen Related Compound A, United States Pharmacopeia (USP) Reference Standard

1285807

Flurbiprofen sodium, United States Pharmacopeia (USP) Reference Standard

BP574

Flurbiprofen sodium, British Pharmacopoeia (BP) Reference Standard

BP046

2-(Biphenyl-4-yl)propionic acid, British Pharmacopoeia (BP) Reference Standard

BP681

4-Acetyl-2-fluorobiphenyl, British Pharmacopoeia (BP) Reference Standard

PHR2710

Flurbiprofen Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard

PHR2711

Flurbiprofen Sodium, certified reference material, pharmaceutical secondary standard

Y0002271

Flurbiprofen for peak identification, CRS, European Pharmacopoeia (EP) Reference Standard

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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R N Brogden et al.
Drugs, 18(6), 417-438 (1979-12-01)
Flurbiprofen, a phenylalkanoic acid derivative, is a non-steroidal anti-inflammatory, antipyretic, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and allied conditions. Published data suggest that flurbiprofen 120 to 150 mg daily is comparable in effectiveness
A Romano et al.
Journal of internal medicine, 241(1), 81-83 (1997-01-01)
Immune-mediated reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are unusual, and true allergy to the drug flurbiprofen has never been documented. We observed a patient who developed a maculopapular rash 48 h after beginning oral therapy with this drug, and 2
Asquad Sultan et al.
The Cochrane database of systematic reviews, (3)(3), CD007358-CD007358 (2009-07-10)
Flurbiprofen is a non-selective non-steroidal anti-inflammatory drug (NSAID), related to ibuprofen and naproxen, used to treat acute and chronic painful conditions. There is no systematic review of its use in acute postoperative pain. To assess efficacy, duration of action, and
F Richy et al.
International journal of clinical practice, 61(8), 1396-1406 (2007-06-29)
The withdrawal of certain cyclooxygenase-2 selective drugs and the availability of over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs) have increased the pressure for researching and prescribing conventional NSAIDs with a favourable efficacy/tolerance ratio in inflammatory diseases, particularly rheumatoid arthritis. The aim of
Laura Gasparini et al.
Brain research. Brain research reviews, 48(2), 400-408 (2005-04-27)
Currently, there is an intense debate on the potential use of nonsteroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease (AD). NSAIDs are among the most widely prescribed drugs for the treatment of pain, fever, and inflammation. Their effects are largely attributed
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