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Supelco

4,4′-MDI

analytical standard

Synonym(s):

4,4′-Methylenebis(phenyl isocyanate), 4,4′-Diphenylmethane diisocyanate, 4,4′-Methylenediphenyl diisocyanate, 4,4′-MDI, Bis(4-isocyanatophenyl)methane

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About This Item

Linear Formula:
CH2(C6H4NCO)2
CAS Number:
101-68-8
Molecular Weight:
250.25
Beilstein:
797662
EC Number:
202-966-0
MDL number:
MFCD00036131
UNSPSC Code:
41116107
PubChem Substance ID:
329754540
NACRES:
NA.24
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grade

analytical standard

Quality Level

100

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

200 °C/5 mmHg (lit.)

mp

42-45 °C (lit.)

density

1.18 g/mL at 25 °C (lit.)

application(s)

environmental

format

neat

storage temp.

−20°C

SMILES string

O=C=Nc1ccc(Cc2ccc(cc2)N=C=O)cc1

InChI

1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2

InChI key

UPMLOUAZCHDJJD-UHFFFAOYSA-N

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General description

4,4′-MDI can be extensively used to make urethane elastomers and urethane coatings.[1]
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food.

Application

4,4′-MDI may be used as an analytical standard for the determination of the analyte in wastewater and air samples,[2][3][4] and human biological samples[5] by various chromatographic techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Inhalation - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

411.8 °F - closed cup

Flash Point(C)

211 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM6182
BCCM3996
BCCF3263
BCBT8693

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Liquid chromatography and mass spectrometry determination of aromatic amines in hydrolysed urine from workers exposed to thermal degradation products of polyurethane
Skarping G, et al.
Chromatographia, 39(9-10), 619-623 (1994)
Sensitive determination of airborne diisocyanates by HPLC: 4, 4?-Diphenylmethane-diisocyanate (MDI)
Schulz M and Salthammer T
Fresenius Journal of Analytical Chemistry, 362(3), 289-293 (1998)
Yan Zhu et al.
Journal of chromatography. A, 956(1-2), 215-220 (2002-07-11)
A method has been developed for the simultaneous determination of a range of aromatic amines using cation-exchange chromatography performed on a standard ion chromatography column using d.c. amperometric detection. The analytes separated were 2,4- and 2,6-toluenediamine (2,4- and 2,6-TDA), aniline
A highly sensitive high-performance liquid chromatographic procedure for the determination of isocyanates in air
Schmidtke F and Seifert B
Fresenius Journal of Analytical Chemistry, 336(8), 647-654 (1990)
Hatada
Macromolecular Design of Polymeric Materials, 40 (1997)
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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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