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AB10516

Sigma-Aldrich

Anti-Angiopoietin-1 Antibody

from rabbit

Synonym(s):

Hepatic fibrinogen/angiopoietin-related protein, PPARG angiopoietin related protein, angiopoietin-like 4, angiopoietin-like 4 protein, angiopoietin-related protein 4, fasting-induced adipose factor, hepatic angiopoietin-related protein, peroxisome prolif

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

horse (95% sequence homology), dog (95% sequence homology), mouse (100% sequence homology), rat (95% sequence homology), bovine (95% sequence homology), mouse, human (90% sequence homology), pig (95% sequence homology)

technique(s)

western blot: suitable

NCBI accession no.

NM_001146.3

UniProt accession no.

O08538

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ANGPT1(284)

General description

The remodelling of the primitive vasculature in mammals to form the mature cardiovascular system includes a number of factors directing endothelial cell development. Angiopoietin-1 is an angiogenic secreted protein that interacts with the endothelial specific Tie-2 receptor. It is primarily expressed in developing endothelial cells. During embryonic development, Ang-1 binds and induces tyrosine phosphorylation of Tie-2. Ang-1 appears to play a crucial role in mediating matrix and mesenchyme. It mediates blood vessel maturation and stability. Ang-1 may play a critical role in heart development. Ang-1 deficient mice mimic the phenotype exhibited by animals deficient in Tie-2. A homolog of Ang-1, termed Angiopoietin-2 may act as an antagonist for Ang-1 and Tie-2. Ang-1 and Ang-2 have ~60% sequence homology.

Specificity

This antibody recognizes Angiopoietin-1.

Immunogen

This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from mouse Angiopoietin-1.

Application

Anti-Angiopoietin-1 Antibody is an antibody against Angiopoietin-1 for use in WB.

Quality

Evaluated by Western Blot in mouse kidney lysate.
Western Blot Analysis: : 1:1,000 dilution of this lot detected Angiopoietin-1 on 10 µg of mouse kidney lysate.

Target description

57 kDa

Physical form

Format: Purified

Analysis Note

Control
Mouse kidney lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mansoor Syed et al.
Nature communications, 8(1), 1173-1173 (2017-10-29)
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Frontiers in neuroscience, 13, 701-701 (2019-07-30)
Xiaoshuan enteric-coated capsule (XSEC) is a Chinese medicinal compound widely used for treatment of ischemic cerebrovascular diseases. Enriched environment (EE) is an effective rehabilitative protocol designed to enhance sensorimotor, cognitive and social stimulation. This study aimed to apply magnetic resonance
Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1/A2 reactive astrocytes.
Feng, et al.
Frontiers in Cellular Neuroscience, 17, 1125412-1125412 (2023)
Angara Sureshbabu et al.
Respiratory research, 16, 4-4 (2015-01-17)
Earlier studies have reported that transforming growth factor beta 1(TGFβ1) is a critical mediator of hyperoxia-induced acute lung injury (HALI) in developing lungs, leading to impaired alveolarization and a pulmonary phenotype of bronchopulmonary dysplasia (BPD). However, the mechanisms responsible for
Defang Pang et al.
Experimental & molecular medicine, 50(9), 117-117 (2018-09-07)
We have previously demonstrated that in response to cerebral ischemia (CI), the growth factor angiopoietin-1 (Ang1) and α5β1 integrin are both induced in cerebral vessels, which likely provide positive signals driving the endogenous angiogenic response and vascular protection after CI.
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