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Sigma-Aldrich

Citric acid-2,2,4,4-d4

98 atom % D, 98% (CP)

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About This Item

Linear Formula:
HOC(CO2H)(CD2CO2H)2
CAS Number:
147664-83-3
Molecular Weight:
196.15
MDL number:
MFCD00209702
UNSPSC Code:
12352106
PubChem Substance ID:
24872074
NACRES:
NA.12

isotopic purity

98 atom % D

Assay

98% (CP)

form

solid

mp

153-159 °C (lit.)

mass shift

M+4

SMILES string

[2H]C([2H])(C(O)=O)C(O)(C(O)=O)C([2H])([2H])C(O)=O

InChI

1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/i1D2,2D2

InChI key

KRKNYBCHXYNGOX-LNLMKGTHSA-N

General description

Citric acid-2,2,4,4-d4 is an isotopic analogue of citric acid .

Application

Citric-2,2,4,4-d4 acid can be used to measure citrate in urine and quantitative profiling of organic acid intermediates of citric acid cycle (CAC).

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B G Keevil et al.
Annals of clinical biochemistry, 42(Pt 5), 357-363 (2005-09-20)
Measurement of urine citrate is used to assess the risk of further urinary stone formation and to assess the benefit of treatment in affected individuals. We wanted to develop a simple and rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method
Orval Mamer et al.
Metabolomics : Official journal of the Metabolomic Society, 9(5), 1019-1030 (2013-12-19)
The quantitative profiling of the organic acid intermediates of the citric acid cycle (CAC) presents a challenge due to the lack of commercially available internal standards for all of the organic acid intermediates. We developed an analytical method that enables
Alex Gomez-Gomez et al.
Journal of pharmaceutical and biomedical analysis, 164, 382-394 (2018-11-23)
Due to its high sensitivity and specificity, liquid chromatography-electrospray tandem mass spectrometry (LC-MS/MS) could be considered as the gold-standard in targeted metabolomics. Although LC-MS/MS allows for the direct detection of a large number of molecules, the proper quantification of highly
Christine S Kim et al.
Cell metabolism, 32(4), 629-642 (2020-09-10)
Stem cells reside in specialized niches that are critical for their function. Upon activation, hair follicle stem cells (HFSCs) exit their niche to generate the outer root sheath (ORS), but a subset of ORS progeny returns to the niche to

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