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288225

Sigma-Aldrich

Chloro(triethylphosphine)gold(I)

97%

Synonym(s):

(Triethylphosphine)gold(I) chloride

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About This Item

Linear Formula:
(C2H5)3PAuCl
CAS Number:
15529-90-5
Molecular Weight:
350.58
EC Number:
239-572-3
MDL number:
MFCD00013205
UNSPSC Code:
12161600
PubChem Substance ID:
24857327
NACRES:
NA.22

Quality Level

100

Assay

97%

form

solid

reaction suitability

core: gold
reagent type: catalyst

bp

210 °C/0.03 mmHg (lit.)

mp

84-86 °C (lit.)

SMILES string

Cl[Au].CCP(CC)CC

InChI

1S/C6H15P.Au.ClH/c1-4-7(5-2)6-3;;/h4-6H2,1-3H3;;1H/q;+1;/p-1

InChI key

SYBBXLKWGHAVHP-UHFFFAOYSA-M

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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G D Hoke et al.
Toxicology and applied pharmacology, 99(1), 50-60 (1989-06-01)
Chlorotriethylphosphine gold(I) (TEPAu) is an organo-gold compound that has therapeutic activity in animal models of rheumatoid arthritis. Initial studies have suggested that TEPAu is a potent cytotoxic compound in vitro against a variety of cultured cell types and isolated hepatocytes.
Maria Pia Rigobello et al.
European journal of pharmacology, 582(1-3), 26-34 (2008-02-05)
In Jurkat T cells, S-triethylphosphinegold(I)-2,3,4,6-tetra-O-acetyl-1-thio-beta-d-glucopyranoside (auranofin) and triethylphosphine gold(I) chloride (TepAu) induced apoptosis, as estimated by DNA fragmentation and visualised by fluorescence microscopy. Apoptosis was characterised by mitochondrial cytochrome c release which was not prevented by cyclosporin A. Apoptosis appeared
The structural flexibility of ferric cytochrome c: regulation of the spin-state equilibrium by an anti-arthritic gold(I) compound at neutral pH.
G Otiko et al.
FEBS letters, 116(2), 227-230 (1980-07-28)
M C Grootveld et al.
Journal of inorganic biochemistry, 27(1), 1-15 (1986-05-01)
Reactions of bacterial Fe(III) cyt b562, HbO2, met Hb and met Mb with Et3PAuCl and Et3PAuNO3 (and some related complexes) have been investigated by electronic absorption and EPR and NMR spectroscopy. Except for met Hb, which denatured, the products were
C P Sung et al.
The Journal of rheumatology, 11(2), 153-157 (1984-04-01)
A number of gold compounds, nonsteroidal antiinflammatory drugs (NSAID) and protease inhibitors have been examined for their ability to inhibit the respiratory burst of peritoneal macrophages. A potent (IC50 = 5 microM or less) dose dependent inhibitory activity was seen
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