HPLC Analysis of Sibutramine Enantiomers on Astec^® CHIROBIOTIC^® V2

材料

分析柱

产品编号

说明

价格

15024AST

Astec^® CHIROBIOTIC^® V2手性HPLC色谱柱

5 μm particle size, L × I.D. 25 cm × 4.6 mm

CONDITIONS

column

CHIROBIOTIC V2, 25 cm x 4.6 mm I.D., 5 μm particles (15024AST)

mobile phase

15 mM ammonium formate in methanol

flow rate

1 mL/min

column temp.

25 °C

detector

UV, 230 nm

injection

10 μL

sample

1 mg/mL in methanol

说明

分析報告

Sibutramine, one of a few drugs approved for long-term treatment of obesity, is a chiral compound. The (R) enantiomer has the desired effect of reducing body weight and food intake, but the (S) enantiomer has the opposite effect: A perfect example of why chiral HPLC is important to pharmaceutical and clinical analysts. Astec^® CHIROBIOTIC^® V2 successfully separates sibutramine enantiomers, using a simple, MS-friendly mobile phase.

法律資訊

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

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Related Product Categories

HPLC Columns GC Columns & Accessories TLC Plates & Adsorbents Solid Phase Microextraction (SPME)Solid Phase Extraction & QuEChERS

Related Applications

Small Molecule HPLC Large Molecule HPLC Gas Chromatography (GC)TLC Solid Phase Microextraction (SPME)Solid Phase Extraction (SPE)QuEChERS

HPLC Analysis of Sibutramine Enantiomers on Astec® CHIROBIOTIC® V2

材料

分析柱