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Zinc and myocardial ischemia/reperfusion injury.

Zinc and myocardial ischemia/reperfusion injury.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine (2013-08-29)

Zhelong Xu, Juan Zhou

摘要

As an important trace element, zinc is required for the normal cellular structure and function, and impairment of zinc homeostasis is associated with a variety of health problems including cardiovascular disease. Zinc homeostasis is regulated through zinc transporters, zinc binding molecules, and zinc sensors. Zinc also plays a critical role in cellular signaling. Studies have documented that zinc homeostasis is impaired by ischemia/reperfusion in the heart and zinc dyshomeostasis may play a role in the pathogenesis of myocardial ischemia/reperfusion injury. Both exogenous and endogenously released zinc may play an important role in cardioprotection against ischemia/reperfusion injury. The goal of this review is to summarize the current understanding of the roles of zinc homeostasis and zinc signaling in myocardial ischemia/reperfusion injury.

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Sigma-Aldrich

锌, dust, <10 μm, ≥98%

Sigma-Aldrich

锌, powder, <150 μm, 99.995% trace metals basis

Sigma-Aldrich

锌, nanopowder, 40-60 nm avg. part. size, ≥99% trace metals basis

Sigma-Aldrich

锌, foil, thickness 0.25 mm, 99.9% trace metals basis

Sigma-Aldrich

锌, granular, 20-30 mesh, ACS reagent, ≥99.8%

锌, foil, 300x300mm, thickness 0.1mm, as rolled, 99.95+%

Sigma-Aldrich

锌, granular, 30-100 mesh, 99%

Sigma-Aldrich

锌, purum, powder

Sigma-Aldrich

锌制备, 5 g/dL Zn⁺² in THF, highly reactive Rieke^®metal

Sigma-Aldrich

锌, sticks, diam. 7-10 mm, 99.97% trace metals basis

Sigma-Aldrich

锌, mossy, ≥99%

Sigma-Aldrich

锌, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.9%, granular

Sigma-Aldrich

锌, shot, <12 mm, 99.99% trace metals basis

Sigma-Aldrich

锌, pieces, 2-14 mesh, 99.9% trace metals basis

Sigma-Aldrich

锌, foil, thickness 0.25 mm, 99.999% trace metals basis

Sigma-Aldrich

锌, foil, thickness 1.0 mm, 99.99% trace metals basis

Sigma-Aldrich

锌, wire, diam. 1.0 mm, 99.995% trace metals basis

Sigma-Aldrich

锌, shot, 5 mm, 99.999% trace metals basis

锌, wire reel, 5m, diameter 1.0mm, 99.99+%

锌, foil, 100x100mm, thickness 0.1mm, as rolled, 99.95+%

锌, foil, 100x100mm, thickness 0.15mm, as rolled, 99.95+%

锌, foil, 50x50mm, thickness 0.1mm, as rolled, 99.95+%

锌, wire reel, 5m, diameter 2.0mm, 99.99+%

锌, foil, 0.5m coil, thickness 0.05mm, as rolled, 99.95+%

锌, wire reel, 0.1m, diameter 1.0mm, 99.999%

锌, foil, 1m coil, thickness 0.025mm, as rolled, 99.95+%

锌, foil, 50x50mm, thickness 0.15mm, as rolled, 99.95+%

锌, foil, 50mm disks, thickness 0.175mm, as rolled, 99.95+%

锌, foil, 150x150mm, thickness 0.15mm, as rolled, 99.95+%

锌, foil, 5m coil, thickness 0.025mm, as rolled, 99.95+%