Rhodium and its compounds as potential agents in cancer treatment.

Rhodium and its compounds as potential agents in cancer treatment.

Critical reviews in oncology/hematology (2002-06-07)

N Katsaros, A Anagnostopoulou

PMID12050021

摘要

The antitumor activity of the inorganic complex cis-diammine-dichloroplatinum(II) (cisplatin) led to the development of other types of non-organic cytostatic drugs. Numerous platinum other platinum and non-platinum metal compounds were shown to be effective against animal model tumors as well as tumors in man. However, the introduction of novel transition metal agents in clinical treatment is exceptionally slow. So far, Ru(II) and Ru(III) complexes have shown very promising properties while the Ru(III) compound, [ImH][trans-Cl4(Me2SO)(Im)Ru(III)] (Im=imidazole, NAMI-A), is the first ruthenium compound that successfully entered phase I clinical trials. Rhodium belongs to the same group as platinum and ruthenium. However, rhodium compounds, analogues to the corresponding platinum and ruthenium compounds that possess significant antitumor properties, were found to be less effective as anticancer agents mainly due to their toxic effects. Dimeric mu-Acetato dimers of Rh(II) as well as monomeric square planar Rh(I) and octahedral Rh(III) complexes have shown interesting antitumor properties.

材料

货号

品牌

产品描述

204218

Sigma-Aldrich

铑, powder, 99.95% trace metals basis

GF74452316

铑, wire reel, 0.05m, diameter 0.5mm, as drawn, 99.9%

GF80841146

铑, foil, 25x25mm, thickness 0.15mm, as rolled, 99.9%

GF57675561

铑, foil, light tested, 25x25mm, thickness 0.05mm, as rolled, 99.9%

GF40539405

铑, foil, 25x25mm, thickness 0.1mm, as rolled, 99.9%

GF72510364

铑, wire reel, 0.5m, diameter 0.25mm, hard, 99.9%

GF44569907

铑, foil, 25x25mm, thickness 0.125mm, as rolled, 99.9%

GF45819995

铑, wire reel, 0.05m, diameter 0.25mm, hard, 99.9%

GF14938005

铑, microfoil, disks, 25mm, thinness 0.1μm, specific density 124μg/cm², permanent mylar 3.5μm support, 99.9%

GF04978963

铑, foil, not light tested, 10x10mm, thickness 0.012mm, as rolled, 99.9%

GF71687357

铑, microfoil, disks, 10mm, thinness 0.1μm, specific density 124μg/cm², permanent mylar 3.5μm support, 99.9%

GF96356559

铑, foil, light tested, 25x25mm, thickness 0.075mm, as rolled, 99.9%

GF35442727

铑, foil, not light tested, 25x25mm, thickness 0.0005mm, permanent polyester support, 99.85%

GF22634120

铑, foil, not light tested, 50x50mm, thickness 0.00075mm, permanent polyester support, 99.85%

GF49946417

铑, microfoil, disks, 10mm, thinness 0.50μm, specific density 620μg/cm², permanent mylar 3.5μm support, 99.99%

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铑, wire reel, 0.05m, diameter 0.12mm, as drawn, 99.9%

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铑, foil, light tested, 25x25mm, thickness 0.05mm, as rolled, x-ray quality, 99.9%

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GF87742659

铑, foil, not light tested, 25x25mm, thickness 0.001mm, permanent polyester support, 99.85%

GF24911726

铑, foil, not light tested, 25x25mm, thickness 0.012mm, as rolled, 99.9%

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铑, wire reel, 0.1m, diameter 0.25mm, hard, 99.9%

GF17496973

铑, wire reel, 0.2m, diameter 0.5mm, as drawn, 99.9%

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铑, foil, light tested, 15x15mm, thickness 0.05mm, as rolled, 99.9%

GF37380089

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铑, wire reel, 0.5m, diameter 0.12mm, as drawn, 99.9%

GF15499413

铑, foil, not light tested, 25x25mm, thickness 0.006mm, as rolled, 99.9%

GF33789550

铑, foil, not light tested, 50x50mm, thickness 0.001mm, permanent polyester support, 99.85%

GF26710680

铑, wire reel, 0.1m, diameter 0.12mm, as drawn, 99.9%

GF38835737

铑, wire reel, 0.2m, diameter 0.12mm, as drawn, 99.9%