Titanium dioxide nanotube modified implants: an animal study on bone formation.

Titanium dioxide nanotube modified implants: an animal study on bone formation.

Journal of nanoscience and nanotechnology (2013-07-19)

Kwi-Dug Yun, Sang-Won Park, Kwang-Min Lee, Hyun-Seung Kim, Mong-Sook Vang, Hong-So Yang, Jeong-Tae Koh, Seong-Soo Kang, Gye-Jeong Oh, Ga-Hyun Kim, Min-Kyung Ji, Gab-Woon Hwang, Hyun-Pil Lim

PMID23862419

摘要

This study examined the bone response to titanium dioxide nanotube modified implants. A total of 24 implants were placed in the femur of 4 beagles. Before placement, screw-shaped implants were classified into 3 groups; machined surface (group M), titanium dioxide nanotube modification of the machined surface (group MN) and titanium dioxide nanotube modification of the RBM surface (group RN). The texture morphology was observed via scanning electron microscopy. Animals were euthanized after 4 and 12 weeks of submerged healing and the histologic and histomorphometric analyses were performed. Groups MN and RN showed a significantly higher percentage of mineralized bone than that in group M (p < 0.05). The results of this in vivo study constitute significant evidence that the presence of the titanium dioxide nanotubes enhance osseointegration of implants.

材料

货号

品牌

产品描述

718467

Sigma-Aldrich

氧化钛（IV）, nanopowder, 21 nm primary particle size (TEM), ≥99.5% trace metals basis

637254

Sigma-Aldrich

氧化钛 (IV)，锐钛矿, nanopowder, <25 nm particle size, 99.7% trace metals basis

14027

Sigma-Aldrich

氧化钛（IV）, puriss., meets analytical specification of Ph. Eur., BP, USP, 99-100.5%

232033

Sigma-Aldrich

氧化钛 (IV)，锐钛矿, powder, 99.8% trace metals basis

14021

Sigma-Aldrich

氧化钛（IV）, ReagentPlus^®, ≥99%

224227

Sigma-Aldrich

钛 (IV) 氧化物，金红石型, powder, <5 μm, ≥99.9% trace metals basis

248576

Sigma-Aldrich

氧化钛 (IV)，锐钛矿, powder, −325 mesh, ≥99% trace metals basis

637262

Sigma-Aldrich

钛 (IV) 氧化物，金红石型, nanopowder, <100 nm particle size, 99.5% trace metals basis

634662

Sigma-Aldrich

氧化钛(IV)，金红石和锐钛矿混合物, nanopowder, <100 nm particle size (BET), 99.5% trace metals basis

366994

Sigma-Aldrich

钛, powder, <45 μm avg. part. size, 99.98% trace metals basis

348791

Sigma-Aldrich

钛, foil, thickness 0.127 mm, 99.7% trace metals basis

267503

Sigma-Aldrich

钛, foil, thickness 0.25 mm, 99.7% trace metals basis

700347

Sigma-Aldrich

氧化钛(IV)，金红石和锐钛矿混合物, nanoparticles, <150 nm particle size (volume distribution, DLS), dispersion, 40 wt. % in H₂O, 99.5% trace metals basis

268496

Sigma-Aldrich

钛, powder, −100 mesh, 99.7% trace metals basis

204757

Sigma-Aldrich

钛 (IV) 氧化物，金红石型, ≥99.98% trace metals basis

204730

Sigma-Aldrich

钛 (IV) 氧化物，金红石型, 99.995% trace metals basis

677469

Sigma-Aldrich

氧化钛（IV）, contains 1% Mn as dopant, nanopowder, <100 nm particle size (BET), ≥97%

460400

Sigma-Aldrich

钛, wire, diam. 0.25 mm, 99.7% trace metals basis

268526

Sigma-Aldrich

钛, sponge, 1-20 mm, 99.5% trace metals basis

369489

Sigma-Aldrich

钛, foil, thickness 2.0 mm, 99.7% trace metals basis

348848

Sigma-Aldrich

钛, foil, thickness 0.025 mm, 99.98% trace metals basis

348805

Sigma-Aldrich

钛, foil, thickness 0.5 mm, 99.99% trace metals basis

767506

Sigma-Aldrich

钛, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.995% trace metals basis

266035

Sigma-Aldrich

钛, wire, diam. 1.0 mm, 99.99% trace metals basis

305812

Sigma-Aldrich

钛, 5-10 mm, ≥99.99% trace metals basis (purity exclusive of Na and K content)

460397

Sigma-Aldrich

钛, foil, thickness 0.127 mm, ≥99.99% trace metals basis

267481

Sigma-Aldrich

钛, foil, thickness 0.25 mm, 99.99% trace metals basis

635057

Sigma-Aldrich

钛 (IV) 氧化物，金红石型, <001>, (single crystal substrate), ≥99.9% trace metals basis, L × W × thickness 10 mm × 10 mm × 0.5 mm

267902

Sigma-Aldrich

钛, wire, diam. 0.81 mm, 99.7% trace metals basis

348864

Sigma-Aldrich

钛, wire, diam. 0.5 mm, 99.99% trace metals basis