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Merck

569522-U

Supelco

Discovery® Cyano (5 µm) HPLC Columns

L × I.D. 10 cm × 3 mm, HPLC Column

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About This Item

分類程式碼代碼:
41115700
eCl@ss:
32110501
NACRES:
SB.52

product name

Cyano HPLC 色谱柱 ®, 5 μm particle size, L × I.D. 10 cm × 3 mm

材料

stainless steel column

agency

suitable for USP L10

產品線

Discovery®

特點

endcapped

製造商/商標名

Discovery®

包裝

1 ea of

標籤範圍

4.5% Carbon loading

參數

≤70 °C temp. range
400 bar pressure (5801 psi)

技術

HPLC: suitable
LC/MS: suitable

長度 × 內徑

10 cm × 3 mm

表面積

200 m2/g

表面覆盖率

3.5 μmol/m2

雜質

<10 ppm metals

基質

silica gel, high purity, spherical base material
fully porous particle

基質活性組

cyano phase

粒徑

5 μm

孔徑

180 Å

工作pH值範圍

2-8

應用

food and beverages

分離技術

hydrophilic interaction (HILIC)
normal phase
reversed phase

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特點和優勢

  • 低疏水性可实现对疏水性化合物的快速洗脱
  • 分析强碱性化合物具有优良的峰形和保留性能
  • 对极性化合物具有较强的保留能力
  • 独特的选择性
  • 保留时间显著小于 C18 柱(通常流动相中所需有机相比例更低)
  • 稳定性好、低流失,适用于 LC-MS 分析
  • 与高含水量的流动相兼容

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法律資訊

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

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E F Nemeth et al.
The Journal of pharmacology and experimental therapeutics, 299(1), 323-331 (2001-09-19)
Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at
Aaron D Milstein et al.
Trends in pharmacological sciences, 29(7), 333-339 (2008-06-03)
Presynaptic glutamate release elicits brief waves of membrane depolarization in neurons by activating AMPA receptors. Depending on its precise size and shape, current through AMPA receptors gates downstream processes like NMDA receptor activation and action potential generation. Over a decade
Aleem Gangjee et al.
Journal of medicinal chemistry, 53(22), 8116-8128 (2010-10-27)
Two classes of molecules were designed and synthesized based on a 6-CH(3) cyclopenta[d]pyrimidine scaffold and a pyrrolo[2,3-d]pyrimidine scaffold. The pyrrolo[2,3-d]pyrimidines were synthesized by reacting ethyl 2-cyano-4,4-diethoxybutanoate and acetamidine, which in turn was chlorinated and reacted with the appropriate anilines to
Xuqing Zhang et al.
Journal of medicinal chemistry, 50(16), 3857-3869 (2007-07-20)
A novel series of pyrazolines 2 have been designed, synthesized, and evaluated by in vivo screening as tissue-selective androgen receptor modulators (SARMs). Structure-activity relationships (SAR) were investigated at the R1 to R6 positions as well as the core pyrazoline ring
Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships

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