V8879

长春新碱 硫酸盐

95.0-105.0% (HPLC), powder or crystals

• 别名: VCR, 醛基长春碱 硫酸盐, 长春醛碱 硫酸盐
• 经验公式（希尔记法）: C₄₆H₅₆N₄O₁₀ · H₂SO₄
• CAS号: 2068-78-2
• 分子量: 923.04
• Beilstein: 3924631
• EC號碼: 218-190-0
• MDL號碼: MFCD00084729
• 分類程式碼代碼: 51111767
• PubChem物質ID: 57654729
• NACRES: NA.85

属性

• 生物源: Streptomyces roseosporus
• 化驗: 95.0-105.0% (HPLC)
• 形狀: powder or crystals
• 儲存條件: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• 顏色: white to light yellow
• 抗生素活性譜: neoplastics
• 作用方式: protein synthesis | interferes
• 儲存溫度: −20°C
• SMILES 字串: OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1
• InChI: 1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
• InChI 密鑰: AQTQHPDCURKLKT-PNYVAJAMSA-N

说明

應用

Vincristine is an antitumor alkaloid isolated from Vinca Rosea. It is used to treat acute leukaemia, malignant lymphoma, Hodgkin′s disease, acute erythraemia, acute panmyelosis, breast cancer, Kaposi′s sarcoma and testicular cancer. Vincristine is widely used in cancer research. It is used to study multi-drug resistance. It is used to inhibit cell cycle progression at M-phase and to inhibit monoamine oxidase (MAO) .

生化／生理作用

Vincristine is a plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing coiled spiral aggregate formation. It arrests cell cycle in G2/M-phase by blocking mitotic spindle formation. Vincristine triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. It inhibits VEGF production in leukemia cell lines. It is a substrate for Pgp and CYP3A4. MRP1 transports vincristine in an ATP- and GSH-dependent manner. Vincristine has some immunosuppressant effect. Vincristine may also interfere with amino acid, cyclic AMP, and glutathione metabolism, calmodulin-dependent Ca2+-transport, cellular respiration, and nucleic acid and lipid biosynthesis.

分析報告

Freely soluble in water, Soluble in methanol, slightly soluble in ethanol

其他說明

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

安全信息

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H300,H341,H361fd
• 防範說明: P202 - P264 - P270 - P280 - P301 + P310 - P405
• 危險分類: Acute Tox. 2 Oral - Muta. 2 - Repr. 2
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable