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About This Item
经验公式（希尔记法）:
C30H49N9O9
CAS号:
分子量:
679.76
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26
推荐产品
product name
Thymopentin, ≥97% (HPLC)
品質等級
化驗
≥97% (HPLC)
形狀
powder
顏色
white
應用
cell analysis
儲存溫度
−20°C
SMILES 字串
CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
InChI
1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1
InChI 密鑰
PSWFFKRAVBDQEG-YGQNSOCVSA-N
Amino Acid Sequence
Arg-Lys-Asp-Val-Tyr
一般說明
Thymopentin (TP5) is a pentapeptide produced by the epithelial cells of the thymic cortex and medulla. It consists of thymosin α1 (Tα1).
生化／生理作用
Thymopentin (TP5) is an immunomodulator, resembling the active site of the thymopoietin. TP5 stimulates cellular immune responses such as T-cell formation, natural killer (NK) cell and macrophage activation, generation of cytokines, and activation of B-cell for antibody production. It also mimics the polypeptide environment of the thymus. TP5 is used to treat conditions like immune deficiency, autoimmune diseases, infections, and cancers. It has a short half-life and is rapidly metabolized in the gastrointestinal tract.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Wendy B London et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(24), 3286-3292 (2011-07-20)
Survival after neuroblastoma relapse is poor. Understanding the relationship between clinical and biologic features and outcome after relapse may help in selection of optimal therapy. Our aim was to determine which factors were significantly predictive of postrelapse overall survival (OS)
Bo Yang et al.
Hematological oncology, 30(3), 115-122 (2012-09-14)
The elderly population is susceptible to haematological malignancies, and these elderly patients are intolerant to cytotoxic drugs. Therefore, the exploration of a safe and reliable strategy exclusive of chemotherapy is critical in improving the prognosis of elderly patients with haematological
Antonia Patruno et al.
Nitric oxide : biology and chemistry, 27(3), 143-149 (2012-06-23)
While thymopentin has been used for many years in the experimental treatment of Sézary syndrome (SS), a rare and very aggressive lymphoma, its mechanism of action is still not known. Herein we show that this peptide acts as an inhibitor
J Duchateau et al.
Medical oncology and tumor pharmacotherapy, 6(1), 19-23 (1989-01-01)
Immunomodulation is interpreted as a temporary alert in a certain part of the immune system. The activation of immune competent cells is presented as a possible basic mechanism of this phenomenon. In the absence of a primary stimulus, immunomodulation remains
G Goldstein et al.
Survey of immunologic research, 4 Suppl 1, 1-10 (1985-01-01)
Thymopoietin is a polypeptide hormone of the thymus consisting of 49 amino acids. The pentapeptide thymopentin (TP-5) Arg-Lys-Asp-Val-Tyr, corresponding to amino acids 32-36 of thymopoietin, appears to represent the active site of thymopoietin in that it has all the biological
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