所有图片(2)
About This Item
线性分子式:
CH3OC6H4CH=C(CN)2
CAS号:
分子量:
184.19
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
化驗
≥98%
形狀
solid
效力
>1250 μM IC50 (negative control)
mp
113-116 °C (lit.)
溶解度
chloroform: soluble 50 mg/mL, clear, light yellow
DMSO: soluble
儲存溫度
2-8°C
SMILES 字串
COc1ccc(cc1)\C=C(/C#N)C#N
InChI
1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
InChI 密鑰
UOHFCPXBKJPCAD-UHFFFAOYSA-N
基因資訊
human ... EGFR(1956)
正在寻找类似产品? 访问 产品对比指南
應用
Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells.
生化／生理作用
Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation,. Furthermore, studies have reported that tyrphostin 1 can block Ca2+ channels and inhibit growth in vascular smooth muscle cells,.
EGFR tyrosine kinase inhibitor.
特點和優勢
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
準備報告
Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
K Qing et al.
Nature medicine, 5(1), 71-77 (1999-01-12)
Adeno-associated virus 2 (AAV)-based vectors have gained attention as a potentially useful alternative to the more commonly used retroviral and adenoviral vectors for human gene therapy. Although AAV uses the ubiquitously expressed cell surface heparan sulfate proteoglycan (HSPG) as a
S Wijetunge et al.
Biochemical and biophysical research communications, 189(3), 1620-1623 (1992-12-30)
Selective inhibitors of tyrosine kinases, tyrphostin 23 and genistein, produced concentration-dependent inhibition of voltage-operated calcium channel currents in vascular smooth muscle cells isolated from rabbit ear artery. The potency of these two structurally dissimilar inhibitors was similar to that reported
Tamer Nasr et al.
European journal of medicinal chemistry, 84, 491-504 (2014-07-23)
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. In this context, new functionalized thiophene, acrylamide, arylhydrazone, pyrazole and pyridone derivatives bearing sulfisoxazole moiety were designed, synthesized and evaluated for their in vitro antibacterial and antifungal
P R Standley et al.
The American journal of physiology, 276(4 Pt 1), E697-E705 (1999-04-13)
Vascular smooth muscle cells (VSMC) subjected to acute or chronic stretch display enhanced growth rates in vitro and in vivo. Clinical examples of vascular hyperplasia (e.g., systolic hypertension and postinjury restenosis) suggest that local insulin-like growth factor I (IGF-I) expression
A Gazit et al.
Journal of medicinal chemistry, 32(10), 2344-2352 (1989-10-01)
A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic series of molecules with a progressive increase in affinity toward the substrate site of the EGF receptor kinase domain. These competitive inhibitors
商品
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门