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Merck

T173

Sigma-Aldrich

硫代-L-瓜氨酸

synthetic, solid

别名:

(S)-2-氨基-5-(硫脲基)戊酸, N5-氨基硫酮基甲基-L-鸟氨酸

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About This Item

经验公式(希尔记法):
C6H13N3O2S
分子量:
191.25
Beilstein:
6844478
MDL號碼:
分類程式碼代碼:
12352204

生物源

synthetic

形狀

solid

顏色

white

溶解度

H2O: >10 mg/mL

儲存溫度

2-8°C

SMILES 字串

N[C@@H](CCCNC(N)=S)C(O)=O

InChI

1S/C6H13N3O2S/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1

InChI 密鑰

BKGWACHYAMTLAF-BYPYZUCNSA-N

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生化/生理作用

神经元和内皮亚型一氧化氮合酶的强效选择性抑制剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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H M Abu-Soud et al.
The Journal of biological chemistry, 269(51), 32318-32326 (1994-12-23)
Heme iron reduction in the nitric-oxide synthases (NOSs) requires calmodulin binding and is associated with increased NO synthesis and NADPH oxidation (Abu-Soud, H. M., and Stuehr, D. J. (1993) Proc. Natl. Acad. Sci., U. S. A. 90, 10769-10772). Here, we
E S Furfine et al.
The Journal of biological chemistry, 269(43), 26677-26683 (1994-10-28)
Potent and selective inhibition of neuronal nitric oxide synthase (nNOS) compared to endothelial NOS (eNOS) and inducible NOS (iNOS) may be useful to treat cerebral ischemia (stroke) and other neurodegenerative diseases. S-Methyl-L-thiocitrulline (Me-TC) and S-ethyl-L-thiocitrulline (Et-TC) inhibited the oxidation of
C Frey et al.
The Journal of biological chemistry, 269(42), 26083-26091 (1994-10-21)
Nitric-oxide synthase (NOS) catalyzes the oxidation of L-arginine to citrulline and nitric oxide (NO). The enzyme is inhibited by a variety of N omega-monosubstituted L-arginine analogs, and some of these compounds are useful in reversing pathologies associated with the overproduction

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