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Merck
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文件

T1500

Sigma-Aldrich

睾酮

≥98%

别名:

17β-羟基-3-氧代-4-雄甾烯, 17β-羟基-4-雄甾烯-3-酮, 4-雄甾烯β-17-醇-3-酮, 反式睾酮

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About This Item

经验公式（希尔记法）:
C19H28O2
CAS号:
58-22-0
分子量:
288.42
Beilstein:
1915399
EC號碼:
200-370-5
MDL號碼:
MFCD00003654
分類程式碼代碼:
51111800
PubChem物質ID:
24899970
NACRES:
NA.77

生物源

synthetic (organic)

品質等級

200

無菌

non-sterile

化驗

≥98%

形狀

powder

藥物控制

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

溶解度

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 18.2 mg/ml
absolute ethanol: soluble 0.5 mg/ml
chloroform: soluble 100 mg/mL, clear, colorless to very faintly yellow
H2O: insoluble
dioxane: soluble
methanol: soluble
methyl oleate: slightly soluble
vegetable oils: soluble

運輸包裝

ambient

儲存溫度

room temp

SMILES 字串

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1

InChI 密鑰

MUMGGOZAMZWBJJ-DYKIIFRCSA-N

基因資訊

human ... AR(367) , EBP(10682) , ESR1(2099) , PGR(5241) , SERPINA6(866) , SHBG(6462)
mouse ... Esr1(13982)
rat ... Ar(24208) , Esr1(24890) , Nr3c1(24413) , Nr3c2(25672) , Pgr(25154)

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應用

睾丸激素已用作研究雄性和雌性大鼠大脑中类固醇激素发育情况的标准品。该激素也已用于评估其对小鼠肌肉质量和信号传导的作用。

生化／生理作用

睾丸分泌的睾酮在目标组织中转变为双氢睾酮，介导睾酮的多种生物作用。雄激素诱导胚胎发生和青春期的男性表型发育。

特點和優勢

该化合物是ADME Tox研究推荐产品。点击此处 ，查看更多ADME Tox精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
该化合物是受体分类及信号转导手册上核受体（类固醇）页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。

準備報告

睾丸激素以 100 mg/ml 的浓度溶于氯仿中，得到透明、无色至微弱的黄色溶液。它也可溶于甲醇、无水乙醇（0.5 mg/ml）、45％（w/v）2-羟丙基-b-环糊精水溶液（18.2 mg/ml）、植物油和二恶烷。微溶于油酸甲酯，不溶于水。

相關產品

产品编号
说明
价格

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Chikwendu Ibebunjo et al.
American journal of physiology. Endocrinology and metabolism, 300(2), E327-E340 (2010-11-04)
Declines in skeletal muscle size and strength, often seen with chronic wasting diseases, prolonged or high-dose glucocorticoid therapy, and the natural aging process in mammals, are usually associated with reduced physical activity and testosterone levels. However, it is not clear
Anne T M Konkle et al.
Endocrinology, 152(1), 223-235 (2010-11-12)
The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex
David J Handelsman
The Journal of clinical endocrinology and metabolism, 91(5), 1646-1653 (2006-02-16)
The objective of the study was to review the rationale underlying the banning of human chorionic gonadotropin (hCG) and estrogen blockers (antiestrogens, specific estrogen receptor modulators, aromatase inhibitors) in sports for male and female athletes in the light of gender
Y Zimmerman et al.
Human reproduction update, 20(1), 76-105 (2013-10-02)
BACKGROUND; Combined oral contraceptives (COCs) reduce levels of androgen, especially testosterone (T), by inhibiting ovarian and adrenal androgen synthesis and by increasing levels of sex hormone-binding globulin (SHBG). Although this suppressive effect has been investigated by numerous studies over many
Frances S Chen et al.
Social cognitive and affective neuroscience, 10(6), 797-800 (2014-09-07)
Physical size and strength are associated with dominance and threat. The current study tested (i) whether men's evaluations of male strangers would be negatively influenced by cues indicating physical formidability, and (ii) whether these evaluations would be influenced by oxytocin
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