SRP6577

TAF1 (1371-1496) GST tag human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• 别名: BA2R, CCG1, CCGS, DYT3, KAT4, NSCL2, TAF1 RNA Polymerase II, TAF2A, TAFII250, TATA Box Binding Protein (TBP)-Associated Factor, XDP
• 分類程式碼代碼: 12352200
• NACRES: NA.32

属性

• 生物源: human
• 重組細胞: expressed in E. coli
• 化驗: ≥95% (SDS-PAGE)
• 形狀: liquid
• 分子量: 41.7 kDa (1371-1496 aa + NT GST Tag)
• 包裝: pkg of 100 μg; pkg of 20 μg
• UniProt登錄號: P21675
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... TAF1(6872)

说明

一般說明

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. TAF1 is a component of transcription factor IID, and binds to core promoter sequences at the transcription start site. TAF1 helps control transcription by both its kinase and histone acetyltransferase enzymatic activities. It interacts with transcriptional activators such as the androgen receptor to promote transcription. Disruption of TAF1 causes dystonia 3 (X-linked torsion dystonia) and decreased apoptosis. This protein product contains the first bromodomain of TAF1.

外觀

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317,H319
• 防範說明: P261 - P264 - P272 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable