重組細胞
expressed in baculovirus infected Sf9 cells
化驗
≥70% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
分子量
~19 kDa
NCBI登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... INCENP(3619)
一般說明
INCENP or inner centromere protein antigens 135/155kDa is a constitutively binding centromere proteins and ′passenger,′ or transiently interacting, proteins. The overexpression of a truncation mutant of chicken INCENP and a chimeric CENPB:INCENP protein in mammalian cell culture disrupted both prometaphase chromosome alignment and completion of cytokinesis. INCENP forms a complex with the evolutionarily conserved family of Aurora B kinases which helps coordinate chromosome segregation, spindle behavior, and cytokinesis during mitosis.
生化／生理作用
As part of the chromosomal passenger complex (CPC), inner centromere protein (INCENP) has a role in assembly and stability of the complex. It also aids in the centromere localization of CPC. INCENP has a role in mitosis and associates with microtubules. The protein has been shown to be upregulated in colorectal cancer cell lines.
外觀
Supplied in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol.
準備報告
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
訊號詞
Danger
危險聲明
危險分類
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow.
Wheatley SP, et.al
Experimental Cell Research, 262(2), 122-127 (2001)
Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer.
Kabisch M, et.al
Carcinogenesis, 36(2), 256-271 (2015)
Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells.
Adams RR, et.al
Chromosoma, 110(2), 65-74 (2001)
INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow.
S P Wheatley et al.
Experimental cell research, 262(2), 122-127 (2001-01-05)
Inner centromere protein (INCENP) is a chromosomal passenger protein with an essential role in mitosis. At the metaphase/anaphase transition, some INCENP transfers from the centromeres to the central spindle; the remainder then transfers to the equatorial cortex prior to cleavage
R R Adams et al.
Chromosoma, 110(2), 65-74 (2001-07-17)
The inner centromere protein (INCENP), which has previously been described in chicken, frog and mouse, is required for correct chromosome segregation and cytokinesis. We have identified the human INCENP gene by library screening and reverse transcription-polymerase chain reaction (RT-PCR) and
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