SRP5350

CRKL, His tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• 别名: crk-like protein
• CAS号: 622897-68-1
• UNSPSC代码: 12352204
• NACRES: NA.32

属性

• 生物来源: human
• 重组: expressed in baculovirus infected Sf9 cells
• 方案: ≥70% (SDS-PAGE)
• 表单: buffered aqueous glycerol solution
• 分子量: ~39 kDa
• NCBI登记号: NM_005207
• 应用: cell analysis
• 运输: dry ice
• 储存温度: −70°C
• 基因信息: human ... CRKL(1399)

说明

一般描述

CRKL or v-crk sarcoma virus CT10 oncogene homolog (avian)-like is a protein kinase containing SH2 and SH3 (src homology) domains that activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase which plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic. CRKL is also required for normal cellular responses to Fgf8, including survival and migration, Erk activation, and target gene expression.

外形

Supplied in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol.

制备说明

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

安全信息

• 象形图: GHS08,GHS07
• 警示用语：: Danger
• 危险声明: H315,H319,H360D
• 预防措施声明: P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• 危险分类: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable