重組細胞
expressed in baculovirus infected Sf9 cells
產品線
PRECISIO®
化驗
≥70% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
比活性
16.2-25.3 nmol/min·mg
分子量
~155 kDa
NCBI登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... PIK3C2A(5286)
一般說明
PIK3C2A is belongs to the phosphoinositide 3-kinase (PI3K) family which play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. PIK3C2A can phosphorylate phosphatidylinositol and phosphatidylinositol-4-phosphate in vitro. PIK3C2A contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases that act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions.
外觀
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
準備報告
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
法律資訊
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Federico Gulluni et al.
Cancer cell, 32(4), 444-459 (2017-10-11)
Proper organization of the mitotic spindle is key to genetic stability, but molecular components of inter-microtubule bridges that crosslink kinetochore fibers (K-fibers) are still largely unknown. Here we identify a kinase-independent function of class II phosphoinositide 3-OH kinase α (PI3K-C2α)
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