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Merck

SRP5025

Sigma-Aldrich

EPHA1 (569-end), active, GST tagged from mouse

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

EPH, EPHT, EPHT1

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.32

重組細胞

expressed in baculovirus infected Sf9 cells

產品線

PRECISIO® Kinase

化驗

≥70% (SDS-PAGE)

形狀

buffered aqueous glycerol solution

比活性

27-37 nmol/min·mg

分子量

~71 kDa

NCBI登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

mouse ... Epha1(13835)

一般說明

EPHA1 is a member of the Eph family of receptor tyrosine kinases that have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the Eph subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EPHA1 seems to be a marker of the differentiated normal epidermis and its downregulation in nonmelanoma skin cancer may contribute to carcinogenesis of these very frequent human tumors. EPHA1 represents a new potential prognostic marker and therapeutic target in nonmelanoma skin cancer.

外觀

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

準備報告

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

法律資訊

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Mechanisms and functions of Eph and ephrin signalling.
Klas Kullander et al.
Nature reviews. Molecular cell biology, 3(7), 475-486 (2002-07-03)
Christian Hafner et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 19(10), 1369-1377 (2006-07-25)
Eph receptors and ephrin ligands represent the largest family of receptor tyrosine kinases. Beyond their well-defined meaning in developmental processes, these molecules also have important functions in adult human tissues and cancer. However, the Eph/ephrin expression profile in human skin

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