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Merck

SRP4809

Sigma-Aldrich

Calretinin from mouse

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)

别名:

CR, Calb2, Calretinin, calbindin 2

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About This Item

分類程式碼代碼:
12352202

生物源

mouse

重組細胞

expressed in E. coli

化驗

≥90% (HPLC)
≥90% (SDS-PAGE)

形狀

solution

分子量

~57 kDa

包裝

pkg of 5 μg

儲存條件

avoid repeated freeze/thaw cycles

雜質

endotoxin, tested

NCBI登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

mouse ... Calb2(12308)

一般說明

Calretinin is a Ca2+-binding protein. It belongs to the EF-hand family. This gene is upregulated in reactive mesothelial cells and in malignant mesothelioma.
Recombinant mouse Calretinin protein is expressed from Escherichia coli and purified by proprietary chromatographic techniques.

生化/生理作用

Calretinin is widely distributed in the brain and might be responsible for neural protection. It regulates calcium signaling in neurons. Absence of calretinin in mice negatively affects long-term potentiation, motor coordination and Purkinje cell activity.

外觀

50 ml (100 μg/ml) in 50 mM Tris-Acetate, pH 7.5, 1 mM EDTA, 20% Glycerol.

重構

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity.
Dong G, et al.
Journal of Neurochemistry, 123, 437-437 (2012)
Calretinin regulates Ca2+-dependent inactivation and facilitation of Ca(v)2.1 Ca2+ channels through a direct interaction with the a12.1 subunit.
Christel CJ, et al.
The Journal of Biological Chemistry, 287, 39766-39766 (2012)
Ayman Alzu'bi et al.
Frontiers in neuroanatomy, 14, 61-61 (2020-09-29)
Secretagogin (SCGN) which acts as a calcium signaling sensor, has previously been shown to be expressed by a substantial population of cortical GABAergic neurons at mid-gestation in humans but not in mice. The present study traced SCGN expression in cortical
Walter Blum et al.
Respiratory research, 16, 153-153 (2015-12-24)
The Ca(2+)-binding protein calretinin is currently used as a positive marker for identifying epithelioid malignant mesothelioma (MM) and reactive mesothelium, but calretinin's likely role in mesotheliomagenesis remains unclear. Calretinin protects immortalized mesothelial cells in vitro from asbestos-induced cytotoxicity and thus
Jonathan D Day-Brown et al.
The Journal of comparative neurology, 525(6), 1403-1420 (2016-03-15)
The tree shrew (Tupaia belangeri) striate cortex is reciprocally connected with the dorsal lateral geniculate nucleus (dLGN), the ventral pulvinar nucleus (Pv), and the claustrum. In the Pv or the dLGN, striate cortex projections are thought to either strongly "drive"

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