生物源
mouse
重組細胞
expressed in E. coli
化驗
≥90% (HPLC)
≥90% (SDS-PAGE)
形狀
solution
分子量
~57 kDa
包裝
pkg of 5 μg
儲存條件
avoid repeated freeze/thaw cycles
雜質
endotoxin, tested
NCBI登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
mouse ... Calb2(12308)
一般說明
Calretinin is a Ca2+-binding protein. It belongs to the EF-hand family. This gene is upregulated in reactive mesothelial cells and in malignant mesothelioma.
Recombinant mouse Calretinin protein is expressed from Escherichia coli and purified by proprietary chromatographic techniques.
Recombinant mouse Calretinin protein is expressed from Escherichia coli and purified by proprietary chromatographic techniques.
生化/生理作用
Calretinin is widely distributed in the brain and might be responsible for neural protection. It regulates calcium signaling in neurons. Absence of calretinin in mice negatively affects long-term potentiation, motor coordination and Purkinje cell activity.
外觀
50 ml (100 μg/ml) in 50 mM Tris-Acetate, pH 7.5, 1 mM EDTA, 20% Glycerol.
重構
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity.
Journal of Neurochemistry, 123, 437-437 (2012)
Calretinin regulates Ca2+-dependent inactivation and facilitation of Ca(v)2.1 Ca2+ channels through a direct interaction with the a12.1 subunit.
The Journal of Biological Chemistry, 287, 39766-39766 (2012)
Frontiers in neuroanatomy, 14, 61-61 (2020-09-29)
Secretagogin (SCGN) which acts as a calcium signaling sensor, has previously been shown to be expressed by a substantial population of cortical GABAergic neurons at mid-gestation in humans but not in mice. The present study traced SCGN expression in cortical
Respiratory research, 16, 153-153 (2015-12-24)
The Ca(2+)-binding protein calretinin is currently used as a positive marker for identifying epithelioid malignant mesothelioma (MM) and reactive mesothelium, but calretinin's likely role in mesotheliomagenesis remains unclear. Calretinin protects immortalized mesothelial cells in vitro from asbestos-induced cytotoxicity and thus
The Journal of comparative neurology, 525(6), 1403-1420 (2016-03-15)
The tree shrew (Tupaia belangeri) striate cortex is reciprocally connected with the dorsal lateral geniculate nucleus (dLGN), the ventral pulvinar nucleus (Pv), and the claustrum. In the Pv or the dLGN, striate cortex projections are thought to either strongly "drive"
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