SRP4542

FGF-19 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• 别名: FGF19, FGFJ, fibroblast growth factor 19
• UNSPSC代码: 12352202
• NACRES: NA.32

属性

• 生物来源: human
• 重组: expressed in E. coli
• 方案: ≥95% (SDS-PAGE)
• 表单: lyophilized
• 效能: 50-200 ng/mL
• 分子量: ~21.8 kDa
• 包装: pkg of 25 μg
• 储存条件: avoid repeated freeze/thaw cycles
• 杂质: endotoxin, tested
• NCBI登记号: NM_005117
• UniProt登记号: O95750
• 运输: wet ice
• 储存温度: −20°C
• 基因信息: human ... FGF19(9965)

说明

一般描述

Fibroblast growth factor-19 (FGF-19) is an ileum-derived polypeptide hormone and a high affinity heparin-dependent ligand for fibroblast growth factor receptor 4 (FGFR4). It is part of the hormone-like FGF family. The gene encoding FGF-19 is localized on human chromosome 11q13.3. Recombinant human FGF-19 is a 21.8kDa protein containing 195 amino acid residues.

生化/生理作用

Fibroblast growth factor-19 (FGF-19) is involved in the gut-liver signaling pathway and modulation of bile acid synthesis. Once secreted, it binds to the hepatic fibroblast growth factor receptor 4 (FGFR4)/Klotho-β cell-surface receptor complex and activates it. FGF-19 promotes glycogen synthesis, protein synthesis and lipid metabolism.

外形

Lyophilized from 5 mM Tris, pH 7.6 plus 75 mM NaCl. The protein may appear as a haze or film, which you may not see at the bottom of the vial.

重悬

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1 to 1.0 μg/μL. This solution can then be diluted into other aqueous buffers.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable