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生物源
human
重組細胞
expressed in E. coli
化驗
≥98% (HPLC)
≥98% (SDS-PAGE)
形狀
lyophilized
分子量
15.8 kDa
包裝
pkg of 10 μg
技術
cell culture | mammalian: suitable
雜質
<0.1 EU/μg endotoxin, tested
顏色
white to off-white
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... IL31(386653)
一般說明
IL-31 (interleukin 31) is a T-cell expressed four helix bundle cytokine that functions as a ligand for a heterodimeric receptor composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor (OSMR). The latter is expressed in epithelial cells and keratinocytes. IL-31 is a member of the gp130/IL-6 (glycoprotein 130) cytokine family. This protein is released by CD4+T cells, and is activated by Th2 (T-helper) cells, peripheral blood and skin-homing CD45RO+ CLA+ (cutaneous lymphocyte-associated antigen-positive) T cells and MCs (mast cells).
Recombinant IL-31 is a 15.8kDa protein containing 141 amino acid residues.
Recombinant IL-31 is a 15.8kDa protein containing 141 amino acid residues.
生化／生理作用
IL-31 (interleukin 31) is implicated in the pathogenesis of inflammatory disorders such as alopecia, atopic dermatitis, itching, airway hypersensitivity, inflammatory bowel disease, and hepatitis B related liver failure. It is a specific and sensitive marker for tuberculous pleurisy, and is capable of differentiating it from malignant pleural effusion. In humans, this cytokine shows significant elevated expression in pruritic, such as atopic dermatitis, but not in non-pruritic, such as psoriasis, forms of chronic skin inflammation. IL-31 is also implicated in the pathogenesis of chronic spontaneous urticaria, prurigo nodularis, and primary cutaneous lymphomas. Variants in this gene might be linked with the development of mastocytosis and the induction of pruritus in mastocytosis patients.
序列
SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T
外觀
Lyophilized from 10 mM Sodium Phosphate, pH 7.5.
重構
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Potential diagnostic value of serum/pleural fluid IL-31 levels for tuberculous pleural effusion.
Gao Y et al
Scientific Reports, 6, 20607-20607 (2016)
IL-31: a new link between T cells and pruritus in atopic skin inflammation.
Sonkoly E et al
The Journal of Allergy and Clinical Immunology, 117(2), 411-417 (2006)
Interleukin-31 Polymorphisms and Serum IL-31 Level in Patients with Mastocytosis: Correlation with Clinical Presen-tation and Pruritus.
Lange M et al
Acta Dermato-Venereologica, 97(1), 47-53 (2017)
Lia Ginaldi et al.
BMC immunology, 16, 60-60 (2015-10-10)
Several inflammatory cytokines play a key part in the induction of osteoporosis. Until now, involvement of the Th2 cytokine interleukin-31 (IL-31) in osteoporosis hadn't yet been studied. IL-31 is a proinflammatory cytokine mediating multiple immune functions, whose involvement in a
Stacey R Dillon et al.
Nature immunology, 5(7), 752-760 (2004-06-09)
T cell-derived cytokines are important in the development of an effective immune response, but when dysregulated they can promote disease. Here we identify a four-helix bundle cytokine we have called interleukin 31 (IL-31), which is preferentially produced by T helper
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