品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear (Warmed)
儲存溫度
2-8°C
SMILES 字串
IC1=CC=C2C(C(N(C(/C=C/C3=CC(C)=CC=C3)=N2)C4=CC=C(C=C4)C(O)=O)=O)=C1
InChI 密鑰
CQEADRMBOXGOAE-LFYBBSHMSA-N
生化／生理作用
Potent and selective cytosolic BAX dimer modulator that effectively induces apoptosis in cancer cells by selectively modulating inactive BAX.
BDM19, a potent BAX dimer modulator with a Kd of 560 nM, selectively binds to the N-terminal trigger site of inactive BAX, thereby inhibiting its dimerization with an IC50 of 5 μM. By stabilizing the inactive conformation of BAX, BDM-19 allosterically activates it, targeting cells containing cytosolic inactive BAX monomers and dimers. This leads to a dose-dependent translocation of BAX to mitochondria, subsequent cytochrome c release, and induction of apoptosis.
BDM19, a potent BAX dimer modulator with a Kd of 560 nM, selectively binds to the N-terminal trigger site of inactive BAX, thereby inhibiting its dimerization with an IC50 of 5 μM. By stabilizing the inactive conformation of BAX, BDM-19 allosterically activates it, targeting cells containing cytosolic inactive BAX monomers and dimers. This leads to a dose-dependent translocation of BAX to mitochondria, subsequent cytochrome c release, and induction of apoptosis.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Nadege Gitego et al.
Nature communications, 14(1), 8381-8381 (2023-12-17)
The BCL-2 family protein BAX is a major regulator of physiological and pathological cell death. BAX predominantly resides in the cytosol in a quiescent state and upon stress, it undergoes conformational activation and mitochondrial translocation leading to mitochondrial outer membrane
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