SML3608

Massonianoside B

≥95% (HPLC)

• 别名: 4-[(2S,3R)-2,3-Dihydro-7-hydroxy-3-(hydroxymethyl)-5-(3-hydroxypropyl)-2-benzofuranyl]-2-methoxyphenyl 6-deoxy-α-L-mannopyranoside
• 经验公式（希尔记法）: C₂₅H₃₂O₁₀
• CAS号: 188300-19-8
• 分子量: 492.52
• MDL编号: MFCD20274727
• UNSPSC代码: 12352200
• NACRES: NA.21

属性

• 质量水平: 100
• 方案: ≥95% (HPLC)
• 表单: powder
• 颜色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 储存温度: -10 to -25°C

说明

生化/生理作用

Cell-permeable, potent, highly selective, reversible and SAM-competitive DOT1L inhibitor

Massonianoside B is a cell-permeable, potent, highly selective, reversible and SAM-competitive DOT1L (disruptor of 4 telomeric silencing 1-like) inhibitor that decreases cellular levels of H3K79 methylation and inhibits the MLL fusion target genes HOXA9 and MEIS1 expression. Massonianoside B exhibits anti-leukemic activity. It is metabolically stable in both human and mouse liver microsomes.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable