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品質等級
化驗
≥98% (HPLC)
形狀
oil
顏色
colorless to yellow
儲存溫度
-10 to -25°C
SMILES 字串
FC(F)(C1=CC([Se][Se]C2=CC=CC(C(F)(F)F)=C2)=CC=C1)F
生化／生理作用
m-Trifluoromethyl-diphenyl diselenide (TFDD) is a brain blood barrier penetrant organoselenium compound that exhibits antinociceptive and antidepressant effects in animal models without development of tolerance or withdrawal sighs. m-Trifluoromethyl-diphenyl diselenide acts as opioid system modulator, which attenuates morphine withdrawal signs in mice. It exhibits antioxidant and anti-inflammatory properties which might contribute to neuro protective effects.
訊號詞
Danger
危險分類
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Cleisson Schossler Garcia et al.
Molecular neurobiology, 58(10), 5078-5089 (2021-07-11)
Chronic pain and depression often coexist sharing common pathological mechanisms, and available analgesics and antidepressants have demonstrated limited clinical efficacy. Evidence has demonstrated that neuronal oxidative stress, apoptosis, and also glucocorticoid receptor dysregulation facilitate the occurrence and development of both
Contribution of Opioid and Nitrergic Systems to m-Trifluoromethyl diphenyl Diselenide Attenuates Morphine-Induced Tolerance in Mice
ACS Chemical Neuroscience, 13(7), 910-919 (2022)
Carolina C Martins et al.
Progress in neuro-psychopharmacology & biological psychiatry, 98, 109803-109803 (2019-11-07)
The opioid withdrawal syndrome is defined as a complex phenomenon involving multiple cellular adaptations, which leads to the emergence of aversive physical and affective signs. The m-trifluoromethyl-diphenyl diselenide (m-CF3-PhSe)2 elicits an antidepressant-like effect by modulating the opioid system in different
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