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Merck

SML3381

Sigma-Aldrich

10-Hydroxy-trans-2-decenoic acid

≥98% (HPLC)

别名:

(E)-10-Hydroxy-2-decenoic acid, 10-HAD, NSC 87516, Royal jelly acid, Trans-10-hydroxy-2-decenoic acid

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About This Item

经验公式(希尔记法):
C10H18O3
CAS号:
分子量:
186.25
MDL號碼:
分類程式碼代碼:
12352106

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

−20°C

InChI

1S/C10H18O3/c11-9-7-5-3-1-2-4-6-8-10(12)13/h6,8,11H,1-5,7,9H2,(H,12,13)/b8-6+

InChI 密鑰

QHBZHVUGQROELI-SOFGYWHQSA-N

生化/生理作用

10-Hydroxy-2-decenoic acid is an orally available royal jelly component that potently inhibits osteoclastogenesis. It binds to free fatty acid receptor 4 (FFAR4) on osteoclasts which inhibits RANKL (receptor activator of nuclear factor-κB (NF-κB) ligand), thereby attenuating the induction of nuclear factor of activated T cells (NFAT) c1. 10-Hydroxy-2-decenoic acid inhibits bone resorption in ovariectomized mice.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Mengmeng You et al.
European journal of pharmacology, 865, 172736-172736 (2019-10-16)
We previously reported that trans-10-hydroxy-2-decenoic acid (10-HDA), the exclusive lipid component of royal jelly (RJ), alleviates Lipopolysaccharide (LPS)-induced neuroinflammation both in vivo and in vitro. However, whether 10-HDA can protect against LPS-induced blood-brain barrier (BBB) damage is largely unexplored. In
Yosuke Tsuchiya et al.
The Journal of biological chemistry, 295(34), 12224-12232 (2020-07-11)
The supplementation of royal jelly (RJ) is known to provide a variety of health benefits, including anti-inflammatory and anti-obesity effects. RJ treatment also reportedly protects against bone loss, but no single factor in RJ has yet been identified as an

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