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Merck
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文件

SML3335

Sigma-Aldrich

DIPQUO

≥98% (HPLC)

别名:

6,​8-​Dimethyl-​3-​(4-​phenyl-​1H-​imidazol-​5-​yl)​-2(1H)​-​quinolinone, 6,8-Dimethyl-3-(4-phenyl-1H-imidazol-5-yl)quinolin-2(1H)-one, RU 0226606

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About This Item

经验公式（希尔记法）:
C20H17N3O
CAS号:
1269365-82-3
分子量:
315.37
MDL號碼:
MFCD18492440
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O=C1NC2=C(C)C=C(C)C=C2C=C1C3=C(C4=CC=CC=C4)N=CN3

生化／生理作用

DIPQUO is a potent activator of the bone marker alkaline phosphatase (ALP) that promotes osteogenesis in human MSCs and zebrafish. DIPQUO potently induces osteoblast differentiation. It promotes bone formation and regeneration in zebra fish. It appears that DIPQUO promotes activation of the β isoform of p38 MAP kinase

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-?
Cell Chemical Biology, 26 (2019)
Brandoch Cook et al.
The Journal of biological chemistry, 296, 100696-100696 (2021-04-26)
Bone fractures are common impact injuries typically resolved through natural processes of osteogenic regeneration and bone remodeling, restoring the biological and mechanical function. However, dysfunctionality in bone healing and repair often arises in the context of aging-related chronic disorders, such

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