SML2963

8-氮鸟嘌呤

≥98% (HPLC)

• 别名: 2-氨基-6-氧-8-氮杂嘌呤, 2-氨基-6-羟基-8-氮杂嘌呤, 癌散
• 经验公式（希尔记法）: C₄H₄N₆O
• CAS号: 134-58-7
• 分子量: 152.11
• Beilstein: 171098
• MDL號碼: MFCD00056937
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• mp: >300 °C (lit.)
• 溶解度: DMSO: 2 mg/mL, clear (warmed)
• 儲存溫度: 2-8°C
• SMILES 字串: NC1=Nc2[nH]nnc2C(=O)N1
• InChI: 1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)
• InChI 密鑰: LPXQRXLUHJKZIE-UHFFFAOYSA-N

说明

生化／生理作用

8-Azaguanine is a triazole-antimetabolite that displays varies pharmacological effects including anticancer, antiviral and antifungal. It is easily incorporated into ribonucleic acids including rRNA and tRNA. 8-Azaguanine appears to alter mRNA splicing in SF3B1 mutant cells. 8-Azaguanine novel immunomodulatory drug (IMiD) that significantly increases the cytotoxicity of NK cells.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable