SML2760

SGC6870

≥98% (HPLC)

• 别名: (R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
• 经验公式（希尔记法）: C₂₃H₂₁BrN₂O₂S
• 分子量: 469.39
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: powder
• 旋光性: [α]/D +260 to +300°, c = 0.5 in methanol
• 颜色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 储存温度: 2-8°C

说明

生化/生理作用

Potent and selective protein arginine methyltransferase PRMT6 inhibitor.

SGC6870 is a potent and selective protein arginine methyltransferase PRMT6 inhibitor (IC₅₀ = 77 nM by cell-free assays; IC₅₀ = 0.8 μM against asymmetric H3R2 dimethylation of overexpressed PRMT6 in HEK293T cells) over all other PRMTs and 23 methyltransferases. The (S)-enantiomer SGC6870N is inactive toward PRMT6 and serves as an excellent control compound.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3