SML2671

Cevipabulin fumarate

≥98% (HPLC)

• 别名: 5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine fumarate, 5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, TTI-237 fumarate
• 经验公式（希尔记法）: C₁₈H₁₈ClF₅N₆O · C₄H₄O₄
• CAS号: 849550-67-0
• 分子量: 580.89
• MDL编号: MFCD31813783
• UNSPSC代码: 41116004
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 储存条件: desiccated
• 颜色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear; H₂O: 5 mg/mL
• 储存温度: −20°C
• SMILES字符串: FC1=CC(OCCCNC)=CC(F)=C1C2=C(N[C@@H](C)C(F)(F)F)N3C(N=C2Cl)=NC=N3.O=C(/C=C/C(O)=O)O
• InChI: 1S/C18H18ClF5N6O.C4H4O4/c1-9(18(22,23)24)28-16-14(15(19)29-17-26-8-27-30(16)17)13-11(20)6-10(7-12(13)21)31-5-3-4-25-2;5-3(6)1-2-4(7)8/h6-9,25,28H,3-5H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t9-;/m0./s1
• InChI key: TUXZQBYIZLWUKK-AFIAKLHKSA-N

说明

生化/生理作用

Cevipabulin (TTI-237) is a potent microtubule-stabilizing agent that binds to tubulin vinblastine binding site, a typical site of binding for microtubule-destabilizing agents. It is likely that cevipabulin, similarly to other triazolopyrimidines, promotes longitudinal tubulin contacts in microtubules, which promotes stabilization of micro-tubule. Cevipabulin exhibits potent cytotoxic activity in cancer cell lines including cell line expressing a high level of P-glycoprotein. It is active in vivo in several mouse xenograft models of human cancer.

potent microtubule-stabilizing agent that binds to tubulin vinblastine binding site

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable