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SML2461

Sigma-Aldrich

LM22B-10

≥98% (HPLC)

别名:

2,2′,2′′,2′′′-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakis[ethanol], 2,2′,2′,2′′′-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol

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About This Item

经验公式（希尔记法）:
C27H33ClN2O4
CAS号:
342777-54-2
分子量:
485.01
MDL编号:
MFCD00483554
UNSPSC代码:
12352200
NACRES:
NA.77

方案

≥98% (HPLC)

表单

powder

颜色

faint blue to green

溶解性

DMSO: 2 mg/mL, clear

储存温度

−20°C

SMILES字符串

ClC1=CC=C(C(C2=CC=C(N(CCO)CCO)C=C2)C3=CC=C(N(CCO)CCO)C=C3)C=C1

InChI key

QCXQLSGBOUUVNH-UHFFFAOYSA-N

生化/生理作用

LM22B-10 is a brain penetrant, potent and selective TrkB and TrkC neurotrophin receptors agonist that improves cell survival and potently accelerated neurite outgrowth. LM22B-10 inhibits binding of BDNF to TrkB-expressing cells and NT-3 to TrkC-expressing cells.
brain penetrant, potent and selective TrkB and TrkC agonist

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000064483
0000064484
0000058263

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Tao Yang et al.
Neuropharmacology, 110(Pt A), 343-361 (2016-06-24)
Neurotrophin (NT) receptors are coupled to numerous signaling networks that play critical roles in neuronal survival and plasticity. Several non-peptide small molecule ligands have recently been reported that bind to and activate specific tropomyosin-receptor kinase (Trk) NT receptors, stimulate their
Tao Zhang et al.
Asian Pacific journal of tropical medicine, 10(12), 1172-1176 (2017-12-23)
To study the influence of glycyrrhetinic acid (GA) on bronchial asthma (BA) smooth muscle proliferation and apoptosis as well as inflammatory factor expression and its molecular mechanism. Male SD guinea pigs were selected and made into asthma models, bronchial asthma

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