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Merck

SML1621

Sigma-Aldrich

OSMI-1

≥98% (HPLC), powder, OGT inhibitor

别名:

(αR)-α-[[(1,2-二氢-2-氧代-6-喹啉基)磺酰基]氨基]-N-(2-呋喃基甲基)-2-甲氧基-N-(2-噻吩甲基)苯乙酰胺, OSMI 1

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About This Item

经验公式(希尔记法):
C28H25N3O6S2
分子量:
563.64
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

product name

OSMI-1, ≥98% (HPLC)

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O=C(N1)C=CC2=C1C=CC(S(N[C@H](C3=C(OC)C=CC=C3)C(N(CC4=CC=CS4)CC5=CC=CO5)=O)(=O)=O)=C2

InChI

1S/C28H25N3O6S2/c1-36-25-9-3-2-8-23(25)27(28(33)31(17-20-6-4-14-37-20)18-21-7-5-15-38-21)30-39(34,35)22-11-12-24-19(16-22)10-13-26(32)29-24/h2-16,27,30H,17-18H2,1H3,(H,29,32)/t27-/m1/s1

InChI 密鑰

IYIGLWQQAMROOF-HHHXNRCGSA-N

應用

OSMI-1(OGT的小分子抑制剂)已可用于邻位连接分析、Sox2(SRY(性别决定区Y)-Box 2)双荧光素酶报告基因检测、Sox2 ELISA(酶联免疫吸附测定)以及其他 体内 方法 ,以研究 O-连接的β-N-乙酰氨基葡萄糖(O-GlcNAc)介导的癌症自我更新基因的调控。它还被用于研究由O-GlcNAc转移酶介导的Hippo途径调节。

生化/生理作用

OSMI-1是一种细胞渗透性OGT(O-GlcNAc转移酶)抑制剂。
在翻译后修饰过程中,OGT可催化 N-乙酰葡糖胺部分与多种蛋白质的连接。抑制OGT活性,可能会降低病毒在感染过程中的复制率,如单纯疱疹病毒性疾病。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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