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product name
OSMI-1, ≥98% (HPLC)
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
O=C(N1)C=CC2=C1C=CC(S(N[C@H](C3=C(OC)C=CC=C3)C(N(CC4=CC=CS4)CC5=CC=CO5)=O)(=O)=O)=C2
InChI
1S/C28H25N3O6S2/c1-36-25-9-3-2-8-23(25)27(28(33)31(17-20-6-4-14-37-20)18-21-7-5-15-38-21)30-39(34,35)22-11-12-24-19(16-22)10-13-26(32)29-24/h2-16,27,30H,17-18H2,1H3,(H,29,32)/t27-/m1/s1
InChI 密鑰
IYIGLWQQAMROOF-HHHXNRCGSA-N
應用
OSMI-1(OGT的小分子抑制剂)已可用于邻位连接分析、Sox2(SRY(性别决定区Y)-Box 2)双荧光素酶报告基因检测、Sox2 ELISA(酶联免疫吸附测定)以及其他 体内 方法 ,以研究 O-连接的β-N-乙酰氨基葡萄糖(O-GlcNAc)介导的癌症自我更新基因的调控。它还被用于研究由O-GlcNAc转移酶介导的Hippo途径调节。
生化/生理作用
OSMI-1是一种细胞渗透性OGT(O-GlcNAc转移酶)抑制剂。
在翻译后修饰过程中,OGT可催化 N-乙酰葡糖胺部分与多种蛋白质的连接。抑制OGT活性,可能会降低病毒在感染过程中的复制率,如单纯疱疹病毒性疾病。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
其他客户在看
O-GlcNAc transferase inhibitors: current tools and future challenges.
Biochemical Society Transactions, 44(1), 88-93 (2016)
O-GlcNAc modification of oncogenic transcription factor Sox2 promotes protein stability and regulates self-renewal in pancreatic cancer.
bioRxiv, 345223-345223 (2018)
Regulation of the hippo-YAP pathway by glucose sensor O-GlcNAcylation.
Molecular Cell, 68(3), 591-604 (2018)
Bioprocess and biosystems engineering, 43(5), 863-875 (2020-01-26)
O-Glycosylation occurs in recombinant proteins produced by CHO cells, but this phenomenon has not been studied extensively. Here, we report that rituximab is an O-linked N-acetyl-glucosaminylated (O-GlcNAcylated) protein and the production of rituximab is increased by thiamet G, an inhibitor
Theranostics, 9(12), 3410-3424 (2019-07-10)
Pancreatic adenocarcinoma (PDAC) claims more than 90% of the patients diagnosed with the disease owing to its aggressive biology that is manifested by high rate of tumor recurrence. Aberrant upregulation in the transcriptional activity of proteins involved in self-renewal like
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