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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
BrC1=C(OC2=C(C(NC)=O)C=CC=C2)N=C(NC3=CC(OC)=C(OC)C(OC)=C3)N=C1
InChI
1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)
InChI 密鑰
NEXGBSJERNQRSV-UHFFFAOYSA-N
應用
SBI-0206965已用于研究其对镉转化的前列腺上皮细胞生长的影响。
生化／生理作用
SBI-0206965 是丝氨酸/苏氨酸自噬起始激酶 ULK1 和 ULK2 的强效选择性抑制剂，对 ULK1 具有选择性。 SBI-0206965对于ULK1的IC50值为108 nM，而对于ULK2为711 nM。 肿瘤细胞需要自噬来清除错误折叠的蛋白质或受损的细胞器。SBI-0206965可抑制mTOR抑制诱导的细胞自噬。 mTOR信号通常在许多肿瘤中过度活跃，并能驱动增殖，所以mTOR抑制剂作为抗癌药物正在被研究。 然而，mTOR抑制也会导致激活依赖于ulk1的自噬生存反应，而mTOR抑制剂的大多数结果最多只能起到细胞抑制作用。 SBI-0206965协同mTOR抑制诱导细胞凋亡和死亡。
由于大多数肿瘤细胞通过自噬机制存活，因此抑制自噬诱导物Unc-51（丝氨酸/苏氨酸蛋白激酶）样自噬激活激酶（ULK1和ULK2）可能在癌症治疗中有用。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Structure and function of the ULK1 complex in autophagy.
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Secretory clusterin (sCLU) plays an important role in tumor development and cancer progression. However, the molecular mechanisms and physiological functions of sCLU in oral cancer is unclear. We examined the impact of sCLU-mediated autophagy in cell survival and apoptosis inhibition
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The AMP-activated protein kinase (AMPK) is principally known as a major regulator of cellular energy status, but it has been recently shown to play a key structural role in cell-cell junctions. The aim of this study was to evaluate the
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