SML1520

GS39783

≥98% (HPLC)

• 别名: GS-39783, N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine, N4,N6-dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
• 经验公式（希尔记法）: C₁₅H₂₃N₅O₂S
• CAS号: 39069-52-8
• 分子量: 337.44
• MDL號碼: MFCD06201849
• 分類程式碼代碼: 12352202
• PubChem物質ID: 329825937

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: faintly yellow to dark yellow
• 溶解度: DMSO: 5 mg/mL, clear (warmed)
• 儲存溫度: room temp
• SMILES 字串: CSc1nc(NC2CCCC2)c(c(NC3CCCC3)n1)[N+]([O-])=O
• InChI: 1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19)
• InChI 密鑰: GSGVDKOCBKBMGG-UHFFFAOYSA-N

说明

生化／生理作用

GS39783 is a positive allosteric modulator (PAM) of GABA-B receptors. GABAB receptor positive allosteric modulators have potential for treatment of many neuro-psychiatric disorders as well as drug dependence and seizures. The receptor is a GPCR expressed throughout the CNS; it acts as both an auto-receptor and heteroreceptor to modulate GABA release and regulate K+ channels and Ca++ channels. GS39783 has been shown to inhibit alcohol self-administration and to have an antipsychotic-like effect in animal models of addiction and schizophrenia, respectively.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H315,H319,H335
• 防範說明: P301 + P312 + P330 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable