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Merck

SML1216

Sigma-Aldrich

雷夫康唑

≥97% (NMR)

别名:

4-[2-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile, BMS-207147, ER-30346

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About This Item

经验公式(希尔记法):
C22H17F2N5OS
分子量:
437.47
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥97% (NMR)

形狀

powder

光學活性

[α]/D -27 to -33°, c = 1 in methanol

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

−20°C

InChI

1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-7-6-17(23)8-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1

InChI 密鑰

OPAHEYNNJWPQPX-RCDICMHDSA-N

生化/生理作用

Ravuconazole (BMS-207147) is a potent and broad spectrum triazole antifungal. Ravuconazole is an inhibitor of sterol biosynthesis by inhibition of cytochrome P450 14α-demethylase, an enzyme in the sterol biosynthesis pathway that leads from lanosterol to ergosterol.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Yara Almeida Machado et al.
Antimicrobial agents and chemotherapy, 64(8) (2020-05-20)
Mining existing agents that enhance the therapeutic potential of ergosterol biosynthesis inhibitors (EBI) is a promising approach to improve Chagas disease chemotherapy. In this study, we evaluated the effect of ravuconazole, an EBI, combined with amlodipine, a calcium channel blocker
Pollyanna Álvaro Spósito et al.
International journal of nanomedicine, 12, 3785-3799 (2017-05-30)
Self-emulsifying drug delivery systems (SEDDSs) are lipid-based anhydrous formulations composed of an isotropic mixture of oil, surfactant, and cosurfactants usually presented in gelatin capsules. Ravuconazole (Biopharmaceutics Classification System [BCS] Class II) is a poorly water-soluble drug, and a SEDDS type

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