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化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
O=C(C1=CC=CC(O)=C1)OC2=C(F)C=CC=C2OC(C3=CC(O)=CC=C3)=O
InChI
1S/C20H13FO6/c21-16-8-3-9-17(26-19(24)12-4-1-6-14(22)10-12)18(16)27-20(25)13-5-2-7-15(23)11-13/h1-11,22-23H
InChI 密鑰
FRSWCCBXIHFKKY-UHFFFAOYSA-N
應用
WZB-117 已被用于研究其在肿瘤干细胞中的肿瘤起始能力。也用于研究葡萄糖拮抗剂对 2-NBDG(2-(N-(7-硝基苯并-2-氧杂-1,3-二唑-4-基)氨基)-2-脱氧葡萄糖)摄取的影响。
生化/生理作用
WBZ 117 是 H1299 肺癌和其他癌细胞中基础葡萄糖转运的抑制剂。
WZB-117 是一种不可逆抑制剂。在癌细胞中,WZB-117 通过在任何葡萄糖浓度下刺激细胞凋亡来防止细胞生长。它靶向肿瘤干细胞的自我更新和肿瘤起始能力。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Modulation of Glucose Takeup by Glucose Transport on the Isolated OHCs.
Neural Plast., 2018, 7-7 (2018)
Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors.
Oncotarget, 8(24), 38193-38193 (2017)
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Cellular glucose uptake is a key feature reflecting metabolic demand of cells in physiopathological conditions. Fluorophore-conjugated sugar derivatives are widely used for monitoring glucose transporter (GLUT) activity at the single-cell level, but have limitations in in vivo applications. Here, we
PloS one, 17(8), e0261801-e0261801 (2022-08-25)
The fluorescent derivative of glucose, 2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)-amino]-D-glucose (2NBDG), is a widely used surrogate reagent to visualize glucose uptake in live cells at single cell resolution. Using CRISPR-Cas9 gene editing in 5TGM1 myeloma cells, we demonstrate that ablation of the glucose transporter
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Like tumour cells, during intraerythrocytic stage, Plasmodium-infected erythrocytes rely completely on glucose absorption from the blood circulation for energy metabolism. Glucose is taken up by glucose transporter 1 (GLUT1) on human red blood cells (RBCs) and glucose transporter 4 (GLUT4)
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