方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to brown
溶解性
DMSO: 15 mg/mL (clear solution)
储存温度
2-8°C
SMILES字符串
OC(=O)CCC(O)=O.COc1cc(NCCCN)c2nccc(C)c2c1Oc3cccc(c3)C(F)(F)F
InChI
1S/C21H22F3N3O2.C4H6O4/c1-13-7-10-27-19-16(26-9-4-8-25)12-17(28-2)20(18(13)19)29-15-6-3-5-14(11-15)21(22,23)24;5-3(6)1-2-4(7)8/h3,5-7,10-12,26H,4,8-9,25H2,1-2H3;1-2H2,(H,5,6)(H,7,8)
InChI key
XFEIMRMBZQODRY-UHFFFAOYSA-N
生化/生理作用
PQ1 binds tightly to connexin 43 and activates intracellular gap junctions. Treatment of the breast cancer cell line T47D with 200 nM PQ1 induces a 30% increase in gap junctional intercellularcommunication (GJIC) and a 90% decrease in cell growth, with no effect on normal breast epithelial cells.
PQ1 is a Gap Junction ctivator; connexin 43 binder.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ying Ding et al.
Anti-cancer drugs, 23(9), 897-905 (2012-05-10)
Gap junctions are intercellular channels connecting adjacent cells, allowing cells to transport small molecules. The loss of gap junctional intercellular communication (GJIC) is one of the important hallmarks of cancer. Restoration of GJIC is related to the reduction of tumorigenesis
Ying Ding et al.
Journal of cancer science & therapy, 4(11), 371-378 (2012-11-01)
Cisplatin is one of the most widely used anti-cancer drugs due to its ability to damage DNA and induce apoptosis. However, increasing reports of side effects and drug resistance indicate the limitation of cisplatin in cancer therapeutics. Recent studies showed
Ying Ding et al.
Apoptosis : an international journal on programmed cell death, 18(9), 1071-1082 (2013-05-17)
Apoptosis, a programmed cell death, is an important control mechanism of cell homeostasis. Deficiency in apoptosis is one of the key features of cancer cells, allowing cells to escape from death. Activation of apoptotic signaling pathway has been a target
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