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化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: >10 mg/mL
儲存溫度
2-8°C
SMILES 字串
COc1cccc(c1)-c2cn(-c3ccc(CCN4CCC(O)CC4)cc3)c5ncnc(N)c25
InChI
1S/C26H29N5O2/c1-33-22-4-2-3-19(15-22)23-16-31(26-24(23)25(27)28-17-29-26)20-7-5-18(6-8-20)9-12-30-13-10-21(32)11-14-30/h2-8,15-17,21,32H,9-14H2,1H3,(H2,27,28,29)
InChI 密鑰
WUPXZZWTHIZICK-UHFFFAOYSA-N
一般說明
CGP77675属于吡咯并嘧啶类抑制剂。
應用
CGP77675已用于生成小鼠扩增的潜能干细胞。
生化／生理作用
CGP77675 是一种有效的 Src 激酶抑制剂。CGP77675对其他蛋白激酶具有选择性，包括Cdc2（>500倍），表皮生长因子（EGF）受体（7.5倍），血管内皮生长因子受体（>50倍），以及v-Abl（15倍）和粘着斑激酶（Fak）（>25倍）。
CGP77675可以预防白介素1β刺激的高钙血症。已知在卵巢切除的小鼠中，它能够预防骨质流失。 CGP77675以其在癌症治疗中的用途而闻名。
特點和優勢
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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