所有图片(1)
About This Item
经验公式（希尔记法）:
C21H17N3O2S
CAS号:
分子量:
375.44
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
yellow to orange
溶解度
DMSO: ≥10 mg/mL
儲存溫度
2-8°C
SMILES 字串
Cc1cc(\C=C2/SC(=O)N(c3ccccc3)C2=O)c(C)n1-c4cccnc4
InChI
1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
InChI 密鑰
NCSHZXNGQYSKLR-UNOMPAQXSA-N
應用
iCRT14可用于Wnt /β-连环蛋白介导的细胞信号转导研究。
生化／生理作用
iCRT14属于噻唑烷二酮类β-连环蛋白反应性转录抑制剂。它可降低散乱蛋白的水平并调节T细胞因子（TCF）与DNA的结合。 它会导致结肠癌细胞中细胞增殖和肿瘤生长减少的持续减弱。
iCRT14是一种Wnt / β-连环蛋白途径抑制剂。它是连环蛋白应答转录（CRT）报告基因的有效抑制剂，以及内源基因靶标。iCRT14还可以剂量依赖性方式破坏β-连环蛋白-TCF4的相互作用，并在结肠肿瘤细胞系中引起G0/G1 的停滞。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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