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Merck
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文件

SCP0080

Sigma-Aldrich

Caspase 2/3 Substrate

≥95% (HPLC), lyophilized

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About This Item

经验公式（希尔记法）:
C34H44N6O15
分子量:
776.74
分類程式碼代碼:
12352202
NACRES:
NA.32

product name

Caspase 2/3 Substrate,

化驗

≥95% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥80%

儲存條件

protect from light

儲存溫度

−20°C

Amino Acid Sequence

Ac-Leu-Asp-Glu-Ser-Asp-AMC

應用

Caspase 2/3 Substrate (Ac-LDESD-AMC) (Acetyl-Leu-Asp-Glu-Ser-Asp-amino-4-methylcoumarin) is a fluorogenic substrate that may be used to detect caspase 2 or caspase 3.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Andreas Schweizer et al.
The Journal of biological chemistry, 278(43), 42441-42447 (2003-08-16)
The cell death protease caspase-2 has recently been recognized as the most apical caspase in the apoptotic cascade ignited during cell stress signaling. Cytotoxic stress, such as that caused by cancer therapies, leads to activation of caspase-2, which acts as
Guoxing Fu et al.
Apoptosis : an international journal on programmed cell death, 13(11), 1291-1302 (2008-09-10)
Caspase-3, -6 and -7 cleave many proteins at specific sites to induce apoptosis. Their recognition of the P5 position in substrates has been investigated by kinetics, modeling and crystallography. Caspase-3 and -6 recognize P5 in pentapeptides as shown by enzyme

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