SBR00121

Amphotericin B water soluble

from semisynthetic, powder

• 别名: AmB, Amphotericin
• 经验公式（希尔记法）: C₅₁H₈₂N₂O₁₉
• 分子量: 1027.20
• 分類程式碼代碼: 51302401

属性

• 生物源: fermentation/recombinant; semisynthetic
• 品質等級: 200
• 化驗: ≥90% (HPLC)
• 形狀: powder
• 儲存條件: protect from light
• 顏色: light yellow to very dark yellow, to very dark brown
• 作用方式: cell membrane | interferes
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 適合性: fungi; yeasts
• InChI: 1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
• InChI 密鑰: APKFDSVGJQXUKY-INPOYWNPSA-N

说明

一般說明

Amphotericin B is a polyene antifungal antibiotic which has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Amphotericin B water soluble is a synthetic derivative of AmB that preserves the antifungal activity but is highly miscible in water up to 100 mg/mL.

生化／生理作用

Mode of Action: Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out. Antimicrobial spectrum: Includes fungi and yeast It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. It forms transmembrane channels by binding to sterols associated with membranes, thereby leading to the leakage of small molecules Amphotericin B elicits toxicity despite being an effective antibiotic for treating mycoses Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium. Amphotericin B is most effective against fungi and yeast.

特點和優勢

Easily soluble in water up to 100mg/mL
Animal component free
Tested for cell toxicity
Aseptically packaged
Can be 0.2µm filtered

準備報告

Amphotericin B water soluble can be directly dissolved in the media to a working concentration of 2.5 mg/L.

其他說明

Product is sensitive to light.

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H372
• 防範說明: P260 - P264 - P270 - P314 - P501
• 危險分類: STOT RE 1
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable