SBR00088

Rilpivirine

≥95% (HPLC), powder

• 别名: 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, R 278474, TMC 278
• 经验公式（希尔记法）: C₂₂H₁₈N₆
• CAS号: 500287-72-9
• 分子量: 366.42
• MDL编号: MFCD11046372
• UNSPSC代码: 51101500

属性

• 质量水平: 100
• 方案: ≥95% (HPLC)
• 表单: powder
• 颜色: white to yellow, or beige
• 抗生素抗菌谱: viruses
• 作用机制: enzyme | inhibits
• 运输: ambient
• 储存温度: −20°C
• SMILES字符串: CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N
• InChI: 1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+
• InChI key: YIBOMRUWOWDFLG-ONEGZZNKSA-N

说明

一般描述

Rilpivirine is an antibiotic which belongs to the class of compounds known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).

生化/生理作用

Nonnucleoside reverse transcriptase inhibitor (NNRTI); anti-retroviral

Rilpivirine inhibits the activity of the reverse transcriptase enzyme, which is essential for the replication of HIV-1. Specifically, it binds to a specific site on the enzyme and blocks its activity, thereby preventing the conversion of viral RNA into DNA, which is an essential step for the integration of viral DNA into host cells.

Rilpivirine is a next generation nonnucleoside reverse transcriptase inhibitor (NNRTI), It has been shown to be active against many HIV strains with mutations that confer resistance to the first-generation NNRTIs.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable