SAB5702787

Anti-Phospho-RB(pSer780) Antibody, clone 8R5F5, Rabbit Monoclonal

• 别名: OSRC,PPP1R130,RB,p105-Rb,pRb,pp110,RB1,Rb
• UNSPSC代码: 12352203
• NACRES: NA.46

属性

• 生物来源: rabbit
• 质量水平: 100
• 物料: colorless
• 克隆: 8R5F5, monoclonal
• 表单: liquid
• 分子量: 106 kDa
• 种属反应性: rat, human, rat
• 浓度: 1.74 mg/mL
• 技术: immunohistochemistry: 1:50 - 1:200; western blot: 1:500 - 1:2000
• 颜色: colorless
• 同位素/亚型: IgG
• 免疫原序列: TLSPI
• UniProt登记号: P06400
• 运输: wet ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... RB1(5925)

说明

一般描述

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

免疫原

A synthetic phosphorylated peptide around S780 of human RB (P06400).

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.

应用

WB, IHC

安全信息

• 象形图: GHS07,GHS09
• 警示用语：: Warning
• 危险声明: H317,H411
• 预防措施声明: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• 危险分类: Aquatic Chronic 2 - Skin Sens. 1
• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 3