SAB5702098

Anti-HMGCR Antibody, clone 6Y9L8, Rabbit Monoclonal

• 别名: HMGCR,LDLCQ3,HMGCR
• UNSPSC代码: 12352203
• NACRES: NA.46

属性

• 生物来源: rabbit
• 质量水平: 100
• 物料: colorless
• 克隆: 6Y9L8, monoclonal
• 表单: liquid
• 分子量: 100 kDa
• 种属反应性: human, rat, rat
• 浓度: 0.21 mg/mL
• 技术: western blot: 1:500 - 1:2000
• 颜色: colorless
• 同位素/亚型: IgG
• 免疫原序列: IKPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLS
• UniProt登记号: P04035
• 运输: wet ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... HMGCR(3156)

说明

一般描述

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

免疫原

A synthetic peptide corresponding to a sequence within amino acids 400-500 of human HMGCR (P04035).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

应用

WB

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 1