SAB5700325

Anti-Phospho-SMC1A-S957 antibody produced in rabbit

• 别名: CDLS2, DXS423E, SB1.8, SMC1, SMC1A, SMC1L1, SMC1alpha, SMCB
• 分類程式碼代碼: 12352203
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: 143
• 物種活性: rat, human, mouse
• 濃度: 0.96 mg/ml
• 技術: immunofluorescence: 1:20-1:100; immunohistochemistry: 1:50-1:200; immunoprecipitation (IP): 1:50-1:100; western blot: 1:500-1:2000
• UniProt登錄號: Q14683
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: phosphorylation (pSer957)
• 基因資訊: human ... SMC1A(8243)

说明

一般說明

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

免疫原

A synthetic phosphorylated peptide around S957 of human SMC1A (NP_006297.2).

外觀

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

儲存和穩定性

Store at -20℃. Avoid freeze / thaw cycles.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable