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Merck
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Key Documents

SAB4702130

Monoclonal Anti-CD22, purified produced in mouse

new

别名:

SIGLEC-2, SIGLEC2

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About This Item

分類程式碼代碼:
12352203

共軛

unconjugated

品質等級

抗體產品種類

primary antibodies

無性繁殖

S-HCL-1, monoclonal

形狀

buffered aqueous solution

物種活性

human

濃度

1 mg/ml

技術

flow cytometry: suitable

同型

IgG2bκ

UniProt登錄號

儲存溫度

2-8°C

目標翻譯後修改

unmodified

基因資訊

human ... CD22(933)

一般說明

CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

特異性

The mouse monoclonal antibody S-HCL-1 (also known as S-HCL1) recognizes an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes.

免疫原

Whole hairy cell leukemia cells and membrane preparation

外觀

Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

準備報告

Purified by protein-A affinity chromatography.

儲存和穩定性

Store at 2-8°C. Do not freeze.

其他說明

The antibody solution should be gently mixed before use.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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