生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 77 kDa
物種活性
human, rat, mouse
濃度
~1 mg/mL
技術
ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... HNRNPM(4670)
一般說明
Anti-HNRNP M Antibody detects endogenous levels of total HNRNP M protein.
HNRNP M (heterogeneous nuclear ribonucleoprotein M) gene is mapped to human chromosome 19p13.2. It codes for a nucleocytoplasmic shuttling RNA binding protein.
免疫原
The antiserum was produced against synthesized peptide derived from human hnRNP M.
Immunogen Range: 11-60
Immunogen Range: 11-60
生化／生理作用
HnRNP M (heterogeneous nuclear ribonucleoprotein M) is an RNA binding protein and participates in mRNA splicing mechanism. It is significantly involved in the formation of mature mRNAs from heterogeneous nuclear RNAs. The encoded protein acts as an important gene expression regulating factor. HnRNPM is involved in the activation of IRES (internal ribosomal entry site)-dependent translation of FGF1 (fibroblast growth factor 1). Thus, this protein is associated with myoblast differentiation. HNRNP M expression is associated with the invasion and metastasis events of tumor cells. Upregulation of HNRNP M is observed in breast cancer and human colorectal epithelial carcinogenesis. Therefore, HnRNP M may serve as an important biomarker for cancer.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Shuijiao Chen et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(5), G394-G403 (2014-01-02)
Colorectal carcinoma (CRC) is one of the most common cancers in the world, and identification of new CRC biomarkers will be helpful for the diagnosis and treatment of CRC. For isobaric tags for relative and absolute quantitation (iTRAQ) analysis, fresh
Huizhi Sun et al.
Genes, chromosomes & cancer, 56(8), 598-607 (2017-04-11)
HnRNPM is an essential splicing factor and its expression is closely correlated with invasion and metastasis of tumor cells. The CD44 cell adhesion molecule is aberrantly expressed in many breast tumors and CD44 splice variants have been implicated in specific
Jacqueline Smith et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 13(6), 310-315 (2002-07-13)
Human Chromosome 19 (HSA19) is virtually completely sequenced. A complete physical contig map made up of BACs and cosmids is also available for this chromosome. It is, therefore, a rich source of information that we have used as the basis
Nadera Ainaoui et al.
PloS one, 10(9), e0136466-e0136466 (2015-09-04)
Fibroblast growth factor 1 (FGF1) is induced during myoblast differentiation at both transcriptional and translational levels. Here, we identify hnRNPM and p54nrb/NONO present in protein complexes bound to the FGF1 promoter and to the mRNA internal ribosome entry site (IRES).
Julienne M Jagdeo et al.
Journal of virology, 89(14), 7064-7078 (2015-05-01)
Picornavirus infection involves a dynamic interplay of host and viral protein interactions that modulates cellular processes to facilitate virus infection and evade host antiviral defenses. Here, using a proteomics-based approach known as TAILS to identify protease-generated neo-N-terminal peptides, we identify
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