生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 86 kDa
种属反应性
mouse, rat, human
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... IKBKB(3551)
一般描述
IKBKB codes for the enzyme, inhibitor of nuclear factor kappa B kinase subunit β (IKK-β/I-K-B kinase 2). It is mapped to human chromosome 8p11.
免疫原
The antiserum was produced against synthesized peptide derived from human IKK-beta.
Immunogen Range: 166-215
Immunogen Range: 166-215
应用
Anti-IKK-β antibody produced in rabbit has been used in western blotting.
生化/生理作用
Inhibitor of nuclear factor kappa B kinase subunit β (IKK-β) acts as a regulator of cell survival and inflammatory response. It promotes cell survival and metabolic adaptation during glutamine deprivation. IKK-β phosphorylates inhibitor of KB proteins and facilitates their degradation. This further leads to the activation of nuclear factor KB (NF-KB) transcription factors. It also phosphorylates β-catenin, tuberous sclerosis 1 (TSC1) and Bcl-2-associated death promoter (BAD).
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor-KB ligand-induced nuclear factor-KB activation in glucocorticoid-induced osteoporosis.
Liu Y, et al.
Experimental and Therapeutic Medicine, 14(5), 4009-4016 (2017)
IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
Michael A. R, et al.
Genes & Development, 30(16), 1837- 1851 (2016)
Canonical nuclear factor KB pathway links tumorigenesis of synchronous mantle-cell lymphoma, clear-cell renal-cell carcinoma, and GI stromal tumor.
Guo R, et al.
Journal of Clinical Oncology, 29(10), e257-e261 (2011)
Deficiency of innate and acquired immunity caused by an IKBKB mutation.
Pannicke U, et al.
The New England Journal of Medicine, 369(26), 2504-2514 (2013)
Yuanxin Liu et al.
Experimental and therapeutic medicine, 14(5), 4009-4016 (2017-10-27)
The current study aimed to improve the understanding on the association between adrenomedullin and osteoporosis in mice with glucocorticoid-induced osteoporosis. Bone resorption and osteoporosis-associated indexes, including maximum load, stiffness, energy to failure, ultimate strength, elastic modulus, post-yield displacement and post-yield
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